Pharmacology at University Of Zambia | Flashcards & Summaries

Lernmaterialien für Pharmacology an der University of Zambia

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TESTE DEIN WISSEN
Drugs acting on PCT
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TESTE DEIN WISSEN
Acetazolamine
Dichlorphenamide
Methazolamide (carbonic anhydrase inhibitors)
Lösung ausblenden
TESTE DEIN WISSEN
Carbonic Anhydrase Inhibitors
MOA
Uses
Adverse Effects
Contraindications
Lösung anzeigen
TESTE DEIN WISSEN
MOA: reabsorbtion of HCO3 and Na
          Block renal CA and ciliary body in eye
          Inhibition = facilitates GABA synthesis
Uses: rare in diuretics
           Mainly treat Glaucoma
           Epilepsy
           Inc alkalinity in urine=excretion of cysteine
Adverse Effects:
  • Drowsiness
  • headache
  • GI disturbances
  • metabolic acidosis
  • hyponatremia
  • hypokalemia
Contraindications: Hepatic cirrhosis  
Lösung ausblenden
TESTE DEIN WISSEN
Loop Diuretics Drugs
Lösung anzeigen
TESTE DEIN WISSEN
Frusemide (most important)
Torsemide
Butemide
Ethacrynic
Lösung ausblenden
TESTE DEIN WISSEN
Loop Diuretics 
MOA
Uses
Adverse Effects
Contraindications
Lösung anzeigen
TESTE DEIN WISSEN
MOA: Acts on asc limb
  • Inhibit Na/K/Cl co transport in thick asc limb
  • Interfere with reabsorbtion of K, Ca and Mg in loop
  • induce renal syn of prostagladins= dilation of Bv and dec in peripheral resistance      
Uses: hypertension in impaired renal function
  • congestive heart failure
  • acute pulmonary edema
  • acute +chronic renal failure
  • Nephrotic syndrome
  • hypercalcemia
  • hyperkalemia
  • chemical intoxication

  • Preferred in Na and water retention treatment
Adverse Effects: hypovolemia
  • electrolyte imbalance
  • CNS effects- ototoxicity, the usual
  • hyperglycemia
  • hyperuriccemia
  • blood dyscraisias
  • hypersensitivity reactions
Contraindications
Lösung ausblenden
TESTE DEIN WISSEN
DCT Thiazides
Lösung anzeigen
TESTE DEIN WISSEN
chlorothiazide
hydrochlorothiazide
bendoflumethiazide
cyclothiazide
Lösung ausblenden
TESTE DEIN WISSEN
DCT Thiazide like drugs
Lösung anzeigen
TESTE DEIN WISSEN
Chlorothalidone
indapamide
metolazone
Lösung ausblenden
TESTE DEIN WISSEN
Thiazide Drugs
MOA
Uses
Adverse Effects

Lösung anzeigen
TESTE DEIN WISSEN
MOA: Inhibit Na transport in DCT= loss of Na and H2O
  • inc loss of K and Mg but reduce Ca excretion by inc parathyroid hormone(may cause hypercalcemia)
  • loss of action in renal failure
  • effective in low GFR
Uses:
  • Mild to moderate hypertension
  • Mild heart failure
  • renal calculi
  • chronic renal failure
  • severe resistant oedema
  • nephrogenic diabetes insipidus
  • idiopathic hypercalcuria
Adverse Effects:
  • hypokalemia
  • hyponatremia
  • orthostatic hypotension
  • hyperuricemia
  • hyperlipidemia
  • metabolic alkalosis
  • hyperglycemia
  • GI distress
  • headache
  • Muscle Spasms

Lösung ausblenden
TESTE DEIN WISSEN
Collecting tubule and Duct Drugs

Lösung anzeigen
TESTE DEIN WISSEN
Aquaporins
Spirinolactone
Triamterene and amiloride


Lösung ausblenden
TESTE DEIN WISSEN
Collecting Tubule and duct hormones
Lösung anzeigen
TESTE DEIN WISSEN
Vasopressin
aldosterone
Lösung ausblenden
TESTE DEIN WISSEN
K Sparing Diuretics
Drugs
Function
Lösung anzeigen
TESTE DEIN WISSEN
Amiloride and Triamterene 
aldosterone antagonist
Enhance diuretic effects of loop and thiazide diuretics
Lösung ausblenden
TESTE DEIN WISSEN
Aldosterone Antag
Drugs
Actions
Uses
Adverse effects
Lösung anzeigen
TESTE DEIN WISSEN
  • Spironolactone + epilerenone
  • Interfere with Na/K exchange in collecting tubules
  • Prevent K being pumped into tubule 
  • dec in Na reabsorb = loss of Na and water
  • Prevent hypokalemia induced by loop/ thiazide diuretics
  • secondary hyperaldosterone due to hepatic cirrohis and ascites
  • Conns syndrome (primary hyperaldosteronism)
  • congestive heart failure
  • Spironolactone + eplerenone
    • hyperkalemia
    • hyperchloremic metabolic acidosis
    • arrythmias
  • spironolactone Anti-androgenic 
    • M=gynecomastia and impotence
    • F=menstrual abnormalities
  • Contraindicated in renal insufficiency
  • caution in hepatic disease
Lösung ausblenden
TESTE DEIN WISSEN
Na Channel Blockers
Drugs
Uses
Adverse Effects
Lösung anzeigen
TESTE DEIN WISSEN

Amiloride
Triamterene
  • Block entry of Na into tubule
  • similar to aldosterone antagonist
  • mild diuretic effect
  • used in conjuction with K
  • Both - contraindicated in renal insufficiency
    • nausea and vomiting
    • diarrhea
    • hyperkalemia
    • metabolic acidosis
    • vent arrythmias
  • Trimeterene Kidney stones
Lösung ausblenden
  • 94 Karteikarten
  • 45 Studierende
  • 0 Lernmaterialien

Beispielhafte Karteikarten für deinen Pharmacology Kurs an der University of Zambia - von Kommilitonen auf StudySmarter erstellt!

Q:
Drugs acting on PCT
A:
Acetazolamine
Dichlorphenamide
Methazolamide (carbonic anhydrase inhibitors)
Q:
Carbonic Anhydrase Inhibitors
MOA
Uses
Adverse Effects
Contraindications
A:
MOA: reabsorbtion of HCO3 and Na
          Block renal CA and ciliary body in eye
          Inhibition = facilitates GABA synthesis
Uses: rare in diuretics
           Mainly treat Glaucoma
           Epilepsy
           Inc alkalinity in urine=excretion of cysteine
Adverse Effects:
  • Drowsiness
  • headache
  • GI disturbances
  • metabolic acidosis
  • hyponatremia
  • hypokalemia
Contraindications: Hepatic cirrhosis  
Q:
Loop Diuretics Drugs
A:
Frusemide (most important)
Torsemide
Butemide
Ethacrynic
Q:
Loop Diuretics 
MOA
Uses
Adverse Effects
Contraindications
A:
MOA: Acts on asc limb
  • Inhibit Na/K/Cl co transport in thick asc limb
  • Interfere with reabsorbtion of K, Ca and Mg in loop
  • induce renal syn of prostagladins= dilation of Bv and dec in peripheral resistance      
Uses: hypertension in impaired renal function
  • congestive heart failure
  • acute pulmonary edema
  • acute +chronic renal failure
  • Nephrotic syndrome
  • hypercalcemia
  • hyperkalemia
  • chemical intoxication

  • Preferred in Na and water retention treatment
Adverse Effects: hypovolemia
  • electrolyte imbalance
  • CNS effects- ototoxicity, the usual
  • hyperglycemia
  • hyperuriccemia
  • blood dyscraisias
  • hypersensitivity reactions
Contraindications
Q:
DCT Thiazides
A:
chlorothiazide
hydrochlorothiazide
bendoflumethiazide
cyclothiazide
Mehr Karteikarten anzeigen
Q:
DCT Thiazide like drugs
A:
Chlorothalidone
indapamide
metolazone
Q:
Thiazide Drugs
MOA
Uses
Adverse Effects

A:
MOA: Inhibit Na transport in DCT= loss of Na and H2O
  • inc loss of K and Mg but reduce Ca excretion by inc parathyroid hormone(may cause hypercalcemia)
  • loss of action in renal failure
  • effective in low GFR
Uses:
  • Mild to moderate hypertension
  • Mild heart failure
  • renal calculi
  • chronic renal failure
  • severe resistant oedema
  • nephrogenic diabetes insipidus
  • idiopathic hypercalcuria
Adverse Effects:
  • hypokalemia
  • hyponatremia
  • orthostatic hypotension
  • hyperuricemia
  • hyperlipidemia
  • metabolic alkalosis
  • hyperglycemia
  • GI distress
  • headache
  • Muscle Spasms

Q:
Collecting tubule and Duct Drugs

A:
Aquaporins
Spirinolactone
Triamterene and amiloride


Q:
Collecting Tubule and duct hormones
A:
Vasopressin
aldosterone
Q:
K Sparing Diuretics
Drugs
Function
A:
Amiloride and Triamterene 
aldosterone antagonist
Enhance diuretic effects of loop and thiazide diuretics
Q:
Aldosterone Antag
Drugs
Actions
Uses
Adverse effects
A:
  • Spironolactone + epilerenone
  • Interfere with Na/K exchange in collecting tubules
  • Prevent K being pumped into tubule 
  • dec in Na reabsorb = loss of Na and water
  • Prevent hypokalemia induced by loop/ thiazide diuretics
  • secondary hyperaldosterone due to hepatic cirrohis and ascites
  • Conns syndrome (primary hyperaldosteronism)
  • congestive heart failure
  • Spironolactone + eplerenone
    • hyperkalemia
    • hyperchloremic metabolic acidosis
    • arrythmias
  • spironolactone Anti-androgenic 
    • M=gynecomastia and impotence
    • F=menstrual abnormalities
  • Contraindicated in renal insufficiency
  • caution in hepatic disease
Q:
Na Channel Blockers
Drugs
Uses
Adverse Effects
A:

Amiloride
Triamterene
  • Block entry of Na into tubule
  • similar to aldosterone antagonist
  • mild diuretic effect
  • used in conjuction with K
  • Both - contraindicated in renal insufficiency
    • nausea and vomiting
    • diarrhea
    • hyperkalemia
    • metabolic acidosis
    • vent arrythmias
  • Trimeterene Kidney stones
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