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basic monomer form, but it also combines to produce a series of multimers of increasing molecular weight
von willebrand disease
Laboratory
Factor VII deficiency
most common "classic" form; partial decrease of ALL sizes of vWF MW multimers occurs
type I vWd
bleeding symptoms correlate with fibrinogen concentration
hypofibrinogenemia
Laboratory findings
factor XIII deficiency
posttraumatic or post operative bleeding of mucosal tissues
dysfibrinogenemia
qualitative abnormality structure and function
dysfibrinogenemia
moderate to severe bleeding spontaneous bleeding, delayed wound healing, unusual scar formation, increased incidence of spontaneous abortion
factor XIII deficiency
Treatment
a- / hypo- fibrinogemia
what are the hereditary disorders of fibrinogen?
These hereditary disorders of fibrinogen are autosomal recessive
Laboratory findings
dysfibrinogenemia
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