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Is HIV-1 a retrovirus
yes
How many types of aids
two types HIV1, HIV2
What is the most infected age group
40-49
what are two states of a virus
- replication defective
-replication competent
What disease does HIV cause?
It causes AIDS
How does HIV-1 work
It kills CD4+ T cells ,
the secretd viral factors and host cell factors cause in bystander cell death , inflammation and release of toher toxins such as very reactive oxygen species.
What is the gene seqeunce of HIV virus?
same gag, pol, envelope
has additional genes:
- Pol helps with antiviral drug resistance
-Vpr- apopotosis
-tat- inflamation, indirect toxicty, apoptosis
-Nef- inflamation, indirect toxicity, apoptosis.
- envelope, apoptosis, inflamation and indirect toxicity.
How long do indivisuals live with HIV?
- The primary infection takes 4-8 weeks
- Stays asymptomatic for 10 years
- Aids 1-4 years
death
Where did HIV come from
it originated from chimpanzee
Viral entry inhibitor
Fusion inhibitors
- T20 is used to modifie the receptor that the HIV-1 fuse from causing the virus to be unable to go into the cell.
Protease inhibitors
So the protease inhibitor prevents core proteins from bieng released causing in inhibition of the muturation of the virus.
Reverse trancriptase inhibitor
1- An inhibitor binds to the reverse trancriptaseand denatures it causing in the viral rna to not be transcribed.
2- inhibitor binds to the DNA chain produced and terminates it .
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