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Name a condition where lack of transcription affects a number of genes
ATRX [a protein that can unwind DNA]
What is the impact of genomics on medicine?
Functional genomics and personalised medicine
What % of the genome codes for proteins?
1.5%
What is the first level of DNA folding?
Nucleosome
- core particle of 8 histones (octamer) : h2a, h2b, h3 and h4 (x2)
The ribosome is not involved in the following:
(b) aminoacylation of tRNA
Lysosomes
cell organelle filled with enzymes needed to break down certain materials in the cell
features of eukaryotic cells
-5-100um
-multicellular organisms
-outermembrane: lipids/proteins
-nucleus: enclosed by membrane
-cytoplasm: enclosed by outer membrane (cytosol, organelle, cytoskeleton)
How many bases of DNA are there?
3.2 billion
How many SNPs do genes have?
~3 million single-nucleotide polymorphisms
how is stratified medicine being used clincically?
breast cancer:
er+ - tamoxifen
her2+ - herceptin
colon cancer:
normal k-ras protein : cetuximab effective at treating colon cancer
Types of stem cells
totipotent, pluripotent, multipotent, unipotent (haemopoietic)
What comprises chromatin?
DNA + proteins (histone molecules)
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