Bak, Viren, Pilze, Cytostatika, IS at Universität Leipzig

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primäre Resitenz

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sekundäre Resitenz

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Parallelresistenz
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Multiresistenz

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Kolonisationsresitenz

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Persister

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was macht der Biofilm
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Wirkprinzip: Betalactame

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Resistenz: Betalactame

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Monobactame

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ESBL
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Propicillin, Azidocillin

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Exemplary flashcards for Bak, Viren, Pilze, Cytostatika, IS at the Universität Leipzig on StudySmarter:

Bak, Viren, Pilze, Cytostatika, IS

primäre Resitenz
AB wirkt grundsätzlich, auch bei erster Gabe  bei bestimmter Keimart nicht, kann von Stamm zu Stamm unterschiedlich sein

Bak, Viren, Pilze, Cytostatika, IS

sekundäre Resitenz
unter Therapie entwickelt durch genetische Fixation z.B. auf plasmiden und Selektionsdruck

Bak, Viren, Pilze, Cytostatika, IS

Parallelresistenz
gegenüber verschiedenen chemisch und pharmakologisch verwandten AB

Bak, Viren, Pilze, Cytostatika, IS

Multiresistenz
gegenüber zahlreichen, nicht verwandten AB

Bak, Viren, Pilze, Cytostatika, IS

Kolonisationsresitenz
Überwucherung durch pathogene Keime bei Verschiebung des Keimgliechgewichts, zB pseudomembranöse Enterocolitis unter Ampicillin oder Clindamycin durch Clost. dif.

Bak, Viren, Pilze, Cytostatika, IS

Persister
Keime, die ohne Resistenz überleben, wahrschnl ruhende Keime-> Rezidive

Bak, Viren, Pilze, Cytostatika, IS

was macht der Biofilm
verhindert das Eindrigen von AB, Ausnahme: Rifampicin
schützt die Erreger vor dem Immunsystem
verhindert "Abwaschen" der Erreger

Bak, Viren, Pilze, Cytostatika, IS

Wirkprinzip: Betalactame
Hemmung der Mureinsynthese (Blockade der D-Ala_Transpeptidase); sekundär bakterizid

Bak, Viren, Pilze, Cytostatika, IS

Resistenz: Betalactame
häufig, durch Betalactamsen oder durch Mutation der Bindeproteine (Mureinsynthasen)

Bak, Viren, Pilze, Cytostatika, IS

Monobactame
Betalactam

Bak, Viren, Pilze, Cytostatika, IS

ESBL
extended spectrum beta-lactamases;
Betalactamasen vor allem Gram-neg. Keime, die alle Betalactame abbauen können

Bak, Viren, Pilze, Cytostatika, IS

Propicillin, Azidocillin
Penicillin G/V
Schmalspektrumpenicilline
nur gr-pos

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