Immunology at Universität Jena

Flashcards and summaries for Immunology at the Universität Jena

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Study with flashcards and summaries for the course Immunology at the Universität Jena

Exemplary flashcards for Immunology at the Universität Jena on StudySmarter:

Cells of innate immunity

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Innate immunity is

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Epitope

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Humoral immunity

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Cell-mediated immunity

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Antigen-presenting cell (APC)

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Cytokines

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Chemokines

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Major histocompatibility complex (MHC)

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T helper cells

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Cytotoxic T cells

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Hematopoietic stem cells (HSCs)

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Exemplary flashcards for Immunology at the Universität Jena on StudySmarter:

Immunology

Cells of innate immunity
macrophages

Immunology

Innate immunity is
(also called natural immunity or native immunity) is essential for defending against microbes in the first few hours or days after infection, before adaptive immune responses have developed. Innate immunity is mediated by mechanisms that are in place even before an infection occurs (hence innate) and that facilitate rapid responses to invading microbes.

Immunology

Epitope
(also determinant) The part of complex antigen that are specifically recognized by lymphocyte

Immunology

Humoral immunity

is mediated by molecules in the blood and mucosal secretions , called antibodies, which are produced by B lymphocytes. Antibodies recognize microbial antigens, neutralize the infectivity of the microbes, and target microbes for elimination by phagocytes and the complement system.

Immunology

Cell-mediated immunity
also called cellular immunity, is mediated by T lymphocytes. Many microbes are ingested by but survive within phagocytes, and some microbes, notably viruses, infect and replicate in various host cells. In these locations the microbes are inaccessible to circulating antibodies. Defense against such infections is a function of cell-mediated immunity, which promotes the destruction of microbes inside phagocytes and the killing of infected cells to eliminate reservoirs of infection.

Immunology

Antigen-presenting cell (APC)

or accessory cell is a cell that displays antigen complexed with major histocompatibility complexes (MHCs) on their surfaces; this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T-cells.

Immunology

Cytokines
are a large group of secreted proteins with diverse structures and functions, which regulate and coordinate many activities of the cells of innate and adaptive immunity.

Immunology

Chemokines
A large subset of structurally related cytokines that regulate cell migration and movement

Immunology

Major histocompatibility complex (MHC)
is a set of genes that code for cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility. The main function of MHC molecules is to bind to antigens derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells.

Immunology

T helper cells
also known as CD4+ cells, are a type of T cell that play an important role in the adaptive immune system. They help the activity of other immune cells by releasing T cell cytokines. These cells help suppress or regulate immune responses. They are essential in B cell antibody class switching, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages.

Immunology

Cytotoxic T cells
also known as Tc, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen.

Immunology

Hematopoietic stem cells (HSCs)

are the stem cells that give rise to other blood cells. This process is called haematopoiesis. This process occurs in the red bone marrow, in the core of most bones.
Hematopoietic stem cells give rise to different types of blood cells, in lines called myeloid and lymphoid. Myeloid and lymphoid lineages both are involved in dendritic cell formation. Myeloid cells include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, and megakaryocytes to platelets. Lymphoid cells include T cells, B cells, and natural killer cells.

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Basiszertifikat im Projektmanagement (GPM) Alfatraining

Englisch

SC für Basiszertifikat im PM

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