Wifo at Universität Heidelberg

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P-GP knockout Maus

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ABC ZNS Erkrankungen

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Different types of biotherapeutics

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Ivermectin und Collie Hunde

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Für was steht ABC transporter?

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Funktionsweise von ABC transportern

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BCRP

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ABC Transporter Vorkommen

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ABC in Hepatocyten

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Ivermectin

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Erreger der Flussblindheit

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Johanniskraut

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Exemplary flashcards for Wifo at the Universität Heidelberg on StudySmarter:

Wifo

P-GP knockout Maus

schnelles Versterben von Mäusen

--> Anlecken von Käfigen (besprüht mit Ivermectin zur Parasitenbekämpfung)

---> immense Bedeutung von ABC Transportern zum Schutz von Giftstoffen

Wifo

ABC ZNS Erkrankungen

ABC Transporter erschweren Behandlung von ZNS Erkrankungen (Zytostatika kommen nicht ins Gehirn)

--> schlechte Überlebenschance

Problem: meist unselektive Inhibitoren der ABC Transporter

- bei selektiver INhibition eines ABCT an BBB: Ersetzen des inhibierten ABCT durch andere ABCT

Wifo

Different types of biotherapeutics

- Interferons and interleukins
- Enzymes
- Hormones
- Anticoagulants and thrombolytics, Blood factors
- Growth factors and bone morphogenetic proteins (BMP)
- Antibody-based drugs → 70% of approved biopharmaceuticals in 2018
- Engineered protein scaffolds.

Wifo

Ivermectin und Collie Hunde

Besitzen Mutation des P-GP

--> gestörte Funktion an der Bluthirnschranke

--> stark neurotoxische Wirkung


außerdem: Shetland, Australian Shepherd,...

Wifo

Für was steht ABC transporter?

ATP-binding casette transporter

Wifo

Funktionsweise von ABC transportern

HYdrolyse von ATP ist Triebkraft für  transmembrane Translokation von Substraten 

--> Export (Eukaryoten) und Aufnahme von Substraten 

Wifo

BCRP

breast cancer resistance protein (ABC)

-zuerst in Brustkrebszellen erkannt

-Halbtransporter (wenige TM, nur 1 NBD) : Dimerisation für Transportpore


Wifo

ABC Transporter Vorkommen

an Barrieregeweben:

-Enterocyte (Darmzelle)

-Hepatocyte (Leberzelle)

-Brain capillary endothelial cell 

-Renal epithelial Zell (Nierenzelle)



Wifo

ABC in Hepatocyten

ABC transporter in Gallenkappilarmembran (Stern)

PgP, MDR3,MRP2, BSEP 

BSEP (bile salt export protein): Gallensalzcarrier: sezernieren Substanzen in Gallenflüssigkeit

Wifo

Ivermectin

Wirkstoff zur Behandlung von Flussblindheit (Onchozercosis)

--> Krankheit in Zentralafrika

--> Eier des Wurmes über Fliegen übertragen 

-> Eier im Blutkreislauf

-> Larvenstadium setzen sich hinter Augen fest (Erblindung)

Wifo

Erreger der Flussblindheit

Onchocerca volvulus

Wifo

Johanniskraut

Induktor für ABCT

-> keine Kombintion mit HIV-I, Immunsuppressiva, ABP

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Humanbiologie

Neurobiologie

Rekombinante Wirkstoffe SS21

OC Praktikum

MolBio P

Chemie Trivialnamen

Zellbiologie

Neurobio

Immunologie - AK

Bioinfo

Tumorbiologie

Biochemie Zellen

Chemie A

Biochemie - Lebewesen

toxikologie

Wifo 2 ich hasse mobi was soll das

Immunologie

Software Engineering

Pharmako

Altklausuren Regubio

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