PharmaTox at Universität des Saarlandes

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Dynamik: Tachyphylaxie

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Kinetik: LADME-Schema 

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Kinetik 0. Ordnung
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Kinetik 1. Ordnung

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Alpha 1 - Sympathomimetika (3, Ind.)

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Indirekte Sympathomimetika (3 Medikamente oder Drogen, Wirkmechanismus)

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Alpha 1 -Adrenozeptor-Antagonisten (3, Ind, UAW)
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“Selektive” ß1-Blocker (4)

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Nichtselektive ß-Blocker (4)

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Zentral wirksame alpha 2 -Adrenozeptor-Agonisten (2, Ind, UAW)

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Urapidil (Wirkung, Ind, KI)
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Exemplary flashcards for PharmaTox at the Universität des Saarlandes on StudySmarter:

Dynamik: Def. Potenz

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Exemplary flashcards for PharmaTox at the Universität des Saarlandes on StudySmarter:

PharmaTox

Dynamik: Tachyphylaxie
Schnell einsetzende Wirkungsabschwächung (zB schon nach zweiter Verabreichung), Dosiserhöhung kann Effekt nicht kompensieren

PharmaTox

Kinetik: LADME-Schema 
Liberation, Absorption, Distribution, Metabolism, Exkretion

PharmaTox

Kinetik 0. Ordnung
Sättigungskinetik, gleichbleibende Maximalgeschwindigkeit, linear

PharmaTox

Kinetik 1. Ordnung
Umsetzungsgeschwindigkeit direkt proportional zur Substratkonzentration, pro Zeit konstanter Anteil umgesetzt, nicht linear, Elimination der meisten Arzneistoffe

PharmaTox

Alpha 1 - Sympathomimetika (3, Ind.)
Phenylephrin, Oxymetazolin, Naphazolin zB
Indikation: Nasenspray/ Tropfen, Abschwellung Schleimhaut bei Rhinitis/ Sinusitis. Augentropfen bei allerg. Konjunktivitis

PharmaTox

Indirekte Sympathomimetika (3 Medikamente oder Drogen, Wirkmechanismus)
Methylphenidat (Ritalin), Kokain, Amphetamine 
WM: Wiederaufnahmehemmung Noradrenalin und Dopamin

PharmaTox

Alpha 1 -Adrenozeptor-Antagonisten (3, Ind, UAW)
Afluzosin, Tamsulosin, Doxazosin
Ind: 2. Wahl Hypertonie (Doxa), BPH, Harnleiterkoliken (Tamsulosin)
UAW: orthostatische Dysregulation bis Kollaps (einschleichen), Tachykardie, Akkomodationsstörungen, Flush ua

PharmaTox

“Selektive” ß1-Blocker (4)
Atenolol, Bisoprolol, Metoprolol, Nebivolol (+ periphere Vasodilatation über NO)

PharmaTox

Nichtselektive ß-Blocker (4)
Carvedilol (+ alpha), Propranolol, Sotalol, Timolol (Augentropfen)

PharmaTox

Zentral wirksame alpha 2 -Adrenozeptor-Agonisten (2, Ind, UAW)
Clonidin, alpha-Methyldopa
Ind: 2. Wahl Hypertonie, Clonidin + Offenwinkelglaukom, Alkoholentzugsdelir (sedierend), Methyldopa + chron. Schwangerschaftshypertonie 1. Wahl
UAW: Müdigkeit, Sedierung, Bradykardie uvm

PharmaTox

Urapidil (Wirkung, Ind, KI)
Wirkung: Blockade postsyn. alpha 1-Rezeptoren –> Abnahme periph. Gefäßwiderstand –> RR-Senkung
+ Stimulation zentraler Serotoninrezeptoren –> Hemmung symphatikotone Gegenregulation
Ind: hypertensive Krise/ Notfall (i.v.), Kombi Hypertonie (p.o.)
KI: Stillzeit, Aortenisthmusstenose, Schwangerschaft strenge Indikationsstellung (hyp. Notfall)

PharmaTox

Dynamik: Def. Potenz
Umso höher, je geringer die Dosis zur Erreichung des halbmaximalen Effekts ist

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Pharmatox 6,7&9 at

ZHAW - Zürcher Hochschule für Angewandte Wissenschaften

Pharmatox 7 at

ZHAW - Zürcher Hochschule für Angewandte Wissenschaften

Pharma at

Universität Ulm

PharmTox at

Universität des Saarlandes

Pharma at

Universität Bonn

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