Hämatologie at Universität Bochum

Flashcards and summaries for Hämatologie at the Universität Bochum

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Study with flashcards and summaries for the course Hämatologie at the Universität Bochum

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

Myeloproliferative Neoplasien MPN

Def

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

Myeloproliferative Neoplasie MPN

Erkrankungen

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

CML

allg.

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Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

CML

Pathologie

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

CML

Phasen

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

CML

Klinik

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

CML

Therapie

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Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

CML

Prognose

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

sekundäre Thrombozytose

Diff

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

Leukozytose

Diff

Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

Lymphozytose

DD 

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Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

Neutrophilie

DD

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Exemplary flashcards for Hämatologie at the Universität Bochum on StudySmarter:

Hämatologie

Myeloproliferative Neoplasien MPN

Def

  • maligne klonale Erkrankung einer oder mehrerer hämatopoetischer Zellreihen
  • normale Differenzierung
  • weitgehend normale Funktion (dagegen MDS: gestörte Funktion)
  • chronischer Verlauf

Hämatologie

Myeloproliferative Neoplasie MPN

Erkrankungen

  • CML
  • Polycyhaemia vera
  • essentielle Thrombozythämie
  • primäre Myelofibrose

Hämatologie

CML

allg.

  • 15% der Leukämien
  • mittleres Erkrankungsalter 50.-60.Lj
  • 1,5/100000/Jahr

Hämatologie

CML

Pathologie

Translokation einer Gensequenz zwischen Chr 9 und 22

daraus folgt BCR-ABL Gensequenz auf Chr 22 (Philadelphia-Chromosom)

dadurch ständig aktive Tyrosinkinase zur Zellteilung

Hämatologie

CML

Phasen

1: chronische Phase ( Blasten <10%)

2: Akzelerationsphase (Blasten 10-20%)

3: Blastenkrise (Blasten >20%), Übergang in akute Leukämie (3/4 AML, 1/4 ALL)

Hämatologie

CML

Klinik

Leukos 50000-300000

pathologische Linksverschiebung

Normozytäre Anämie

Thrombos hoch/normal/niedrig

Splenomegalie

Knochenschmerzen durch verstärkte Proliferation im KM


Hämatologie

CML

Therapie

Tyrosinkinaseinhibitor ( initial Imatinib)

ggf allogene Stammzelltransplantation

Hämatologie

CML

Prognose

wenn durch Tyrosinkinaseinhibitoren eine komplette molekulargenetische Remission errreicht wird 96% Überlebenschance

Hämatologie

sekundäre Thrombozytose

Diff

  • Eisenmangel
  • Zn Splenektomie
  • Entzündung
  • Infektion
  • Tumor
  • Lymphom
  • rheumatische Erkrankung

Hämatologie

Leukozytose

Diff

  • Infektionen
  • chronisch entzündliche Erkrankungen
  • NPL
  • metabolische Erkrankungen
  • Medikamente
  • Intoxikationen
  • Stress, Traume, Rauchen

Hämatologie

Lymphozytose

DD 

mäßige Leukozytose

  • virale Erkrankungen
  • TBC, Toxoplasmose
  • bakterielle Infektionen in Abheilung
  • ALL


ausgeprägte Leukozytose

  • ALL
  • CLL
  • infektiöse Mononukleose

Hämatologie

Neutrophilie

DD

  • bakterielle Infekte
  • chronisch entzündliche Erkrankungen

             CED, chron. Bronchitis, rheumatische Erkrankungen

  • metabolische Erkrankungen

             Thyreotoxikose, diab/hep Koma, Urämie

  • Malignome

              AML, CML, PV, Myelofibrose

  • Z.n. Splenektomie
  • Blei/Quecksilberintoxikation

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