Advanced Chemical Engineering at Universität Bochum

Flashcards and summaries for Advanced Chemical Engineering at the Universität Bochum

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Study with flashcards and summaries for the course Advanced Chemical Engineering at the Universität Bochum

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

What are the different steps from recombinant DNA to commercialisation?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

On what the bioprocess engineering based?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

What are the different scales?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

Why do you need models before?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

How do you scale up a reactor?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

What is important to define a system?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

Why can be the input different to the output of a system?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

Which parts are important for the material balance in a system?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

How does the material balances accumulation looks like?

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How to use material balances?

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For what do you need energy?

Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

What types of energy excised?

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Exemplary flashcards for Advanced Chemical Engineering at the Universität Bochum on StudySmarter:

Advanced Chemical Engineering

What are the different steps from recombinant DNA to commercialisation?
1. Biochemicals + 2. Animal tissue (material) 3. Select part of animal chromosome (specific gene) 4. Cut out the gene from the animal chromosome 5. Select an microorganism such as E. coli 6. Isolate the plasmid 7. Cut the plasmid 8. Recombinant the plasmid with the animal gene 9. Insertion the plasmid with the gene into a new microorganism as a chassis 10. Plasmid multiplication and gene expression 11. Cell division 12. Small-scale culture --> Replication of the new microorganism 13. Bench-top bioreactor --> Replication in bigger 14. Pilot-scale bioreactor --> Bigger 15. Industrial-scale operation --> The production for the economics 16. Product recovery 17. Packaging and marketing

Advanced Chemical Engineering

On what the bioprocess engineering based?
- Models and science out of: --> First principles --> Empirical models - know-how and experience - Trial-and-error - Driven by economic goals

Advanced Chemical Engineering

What are the different scales?
Going bigger: - Bench-top (100ml - ~ 100l) - Pilot scale (~ 5 000l) - Industrial scale (to megatons per year)

Advanced Chemical Engineering

Why do you need models before?
- Fundermental understanding - Plausibility - Engineering Purposes --> Design and scale up --> Measurement --> Control --> Optimisation --> Sensitivity

Advanced Chemical Engineering

How do you scale up a reactor?
With the 14 step plan

Advanced Chemical Engineering

What is important to define a system?
- Define a system = define its boundary - Can have physical existence or be conceptual

Advanced Chemical Engineering

Why can be the input different to the output of a system?
- Consumed - generated - Accumulates - The system can has a leak

Advanced Chemical Engineering

Which parts are important for the material balance in a system?
- Input - Output - Consumption - Generation - Accumulation

Advanced Chemical Engineering

How does the material balances accumulation looks like?
(mass in through boundaries) + (mass generated in system) - (mass out through boundaries) - (mass consumed in system)

Advanced Chemical Engineering

How to use material balances?
1. Draw a flowsheet 2. Choose a convenient basis (1h or 1 day) 3. Make a list of components included: - Input/fed into - Output from - Consumed in - Generated in 4. Make equations that describe the process 5. Make assumption if necessary (steady state, etc.)

Advanced Chemical Engineering

For what do you need energy?
- Cooling processes - Steam water processes - Control temperature

Advanced Chemical Engineering

What types of energy excised?
- Kinetic energy Ek - Potential energy Ep - Internal energy U

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