Biochemie at TU München

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Welche GLUT gibt es und was machen sie

1 basale Glc Versorgung

2 Hepatozyten und beta Zellen des Pankreas= Sensor - sehr niedrig affin f Glc - Reaktion nur bei sehr hohen Werten --> Zellen reagieren mit Glykogensynthese/ Insulin

3 basale Glc Versorgung Nervenzellen

4 v.a Skelettmuskulatur und Adipozyten - INSULINABHÄNGIGER Transport

5 Fructose

va aktiven transport(2ndär) SGLT gibt es auch noch! Na Antiport/ Symport

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Gs Rez Liganden

Katze hisst die vase, trinkt das glucagon draus, löst fantastische trauben aus der prostata
LSH FSH TSH

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Wie teilt man Oxireductasen ein?

DH
Oxidase
Hydro Peroxidase H2O2 im spiel, entgiftung, 2 e übertragen darauf sodass 2 H2O entstehen
Dihydroxylasen OH dran
Monohydroxylasen

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Bei welchem pH fällt einProtein am leichtesten aus?

Am pI

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Welcher Energiegewinnungsprozess läuft in Erys ab, wozu

Glykolyse,ATP zur Produktion v Glutathion, Regen v Thiolgruppen in Prot und Entgiftung von Peroxiden - Praktikum

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Wo ist die Glucoseresorption unabhängig von Insulin?

In der Darmmuskosa. -Diabetiker haben ja erhöhte BLUT Glucose

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Welche Lipide gobt es, welche sind in Membranen und welche Fkt erfüllen sie?

Glykolipide (Triacylglyceride, nicht i Membran!) , Phospholipide(—glyceride haben 2Fettsäureketten bloss!, phosphosphingolipide), Cholesterin, Sphingolipide

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Was macht die Carboanhydrase

Co2 + H2O—> Kohlensäure HO COOH, gibt ein H+ ab (instabil aber nichts besonderes)
Hydrogencarbonat entsteht
es ist eigentlich eh eine spontane Reaktion aberdie Carboanhydrase

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Amyloidosen

PMD protein misfolding disease
UPR unfolded protein response- Zellmechanismus zum Schutz

sie aggregieren weitere Prot
assoz mit Plaques v Prionen zB u Amyloiden aus Peptiden
neurodegener Erkr (Alzheimer)
TSE tramsmissible spongiforme Enzephalopathie

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Welche 3 Wege müssen in der Gluconeogenese umgangen werden? Neue Enzyme

Pyr zu PEP. Pyr Kinase - Pyrcarboxylase zu Oxalacetat iMt. und dann PEPCK iCsol
Frc 1,6 zu Frc 6 P. Phosphofructokinase- Frc1,6 Bisphosphatase
Glc6 zu Glc. Hexokinase. — Glc 6 Phosphatase ER

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Proteinmodif Wo und Was

nicht cytosolische kommen a RER
mittels Signalseq Nterminal
SRParticle erkennts, a SRP Rezeptor, dann durchgeschleust-Translokon

RER Lumen Signalpeptidase spaltets ab
Glykosylierung
->
a Golgi

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Was passiert mit Molekülen aus dem CC?

zahlreiche Synthesewege,
aKeto—Glu— GABA
Oxalacetat—Asp
Succinyl— Häm Synthese
Citrat— Fettsäuresynthese+Cholesterinsynthese

freiwerdende E wird i Redäquiv gespeichert

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Flashcards and summaries for Biochemie at the TU München

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