Drugs at Radboud University | Flashcards & Summaries

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Lernmaterialien für Drugs an der Radboud University

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Why should alcohol and benzodiazepines not be taken together?
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Because their actions on the GABA receptor summate 
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What determines the dosage in which the drug enters the brain?
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the length of the route to the brain (longer route -> higher dosage needed for the same effect)
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Which cells is the capillary network in the brain and body composed of?
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Endothelial cells (one layer builds a capillary)
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What are endothelial cells in the brain surrounded of / covered?
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End feet of astrocytes are attached to and cover most of the capillary wall
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What is GHRH?
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Growth hormone releasing hormone
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What are small blood vessels called?
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Capillaries
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Is caffeine an ardenosine antagonist or agonist?
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Antagonist: it blocks its receptors without activating them
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Two main effects drugs can have at a synapse
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They can be antagonists or agonists of neurotransmitters (depending on excitatory of inhibitory function of the transmitter, it can support excitation or inhibition)
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What is behavioral myopia?
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„Nearsightedness“: the tendency under the influence of e.g. alcohol to respond to a limited amount of cues (immediate and prominent) while ignoring others (remote cues).
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What does cross-tolerance mean?
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Tolerance for one drug is carried over to a different member of the drug group
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In three brain regions there is no blood brain barrier, which are those regions and why does it lack?
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Pituitary gland: source of hormones released into blood
Pineal gland: chemicals have to enter to affect day and night cycles
area postrema: toxic substances from the blood can enter to induce vomiting
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What do drugs have to pass before entering the brain?
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Blood-brain barrier
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Beispielhafte Karteikarten für deinen Drugs Kurs an der Radboud University - von Kommilitonen auf StudySmarter erstellt!

Q:
Why should alcohol and benzodiazepines not be taken together?
A:
Because their actions on the GABA receptor summate 
Q:
What determines the dosage in which the drug enters the brain?
A:
the length of the route to the brain (longer route -> higher dosage needed for the same effect)
Q:
Which cells is the capillary network in the brain and body composed of?
A:
Endothelial cells (one layer builds a capillary)
Q:
What are endothelial cells in the brain surrounded of / covered?
A:
End feet of astrocytes are attached to and cover most of the capillary wall
Q:
What is GHRH?
A:
Growth hormone releasing hormone
Mehr Karteikarten anzeigen
Q:
What are small blood vessels called?
A:
Capillaries
Q:
Is caffeine an ardenosine antagonist or agonist?
A:
Antagonist: it blocks its receptors without activating them
Q:
Two main effects drugs can have at a synapse
A:
They can be antagonists or agonists of neurotransmitters (depending on excitatory of inhibitory function of the transmitter, it can support excitation or inhibition)
Q:
What is behavioral myopia?
A:
„Nearsightedness“: the tendency under the influence of e.g. alcohol to respond to a limited amount of cues (immediate and prominent) while ignoring others (remote cues).
Q:
What does cross-tolerance mean?
A:
Tolerance for one drug is carried over to a different member of the drug group
Q:
In three brain regions there is no blood brain barrier, which are those regions and why does it lack?
A:
Pituitary gland: source of hormones released into blood
Pineal gland: chemicals have to enter to affect day and night cycles
area postrema: toxic substances from the blood can enter to induce vomiting
Q:
What do drugs have to pass before entering the brain?
A:
Blood-brain barrier
Drugs

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