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which of the following is not very selective?
Phase 2
WHİCH DRUGS ARE EXPOSED TO HYDROXYLATİON?
amphetamines, barbiturates,phenytoin,warfarin
which cytochromes are responsible for phase 1 reactions?
cytochrome P450, especially CYP3A4/5 and CYP2D6
which of the following is lipid-soluble and can pass to the fetus?
thiopental
which drug is converted to active products by metabolism? (in phase 1)
-acetaminophen
which drugs are inducers of drug metabolism? (PCRAPS)
--phenobarbital
-carbamazepine
-rifampin
-alcohol
-phenyotin
-St. Johns Wort
what are the phase 1 reactions?
oxidation
reduction
hydrolysis
which reaction in phase 2 is associated with genetic polymorphism?
-acetylation
what are the properties of phase 2 reactions?
addition (conjugation) of subgroup
not very selective
produce less lipid soluble molecules
which drugs are inhibitors of drug metabolism? (GPACMAN)
-grapefruit
-protease inhibitors
-azole antifungal
-cimetidine
-macrolides
-amiodarane
-Non-DHP CCB
which drugs are exposed to N-dealkylation? (phase 1 reaction)
-caffeine, morphine
Toxic drugs for fetus?
-Opioids
-ACEIs
-Diethylstilboestrol
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