Chemotherapeutic Agents an der University Of Stellenbosch | Karteikarten & Zusammenfassungen

Lernmaterialien für Chemotherapeutic Agents an der University of Stellenbosch

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What is the Narrow-action spectrum resistance?

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When only a few bacterial cell types are affected. e.g. Penicillin G

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What is Broad-spectrum resistance?

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When various bacterial cell types are
affected. e.g.Tetracycline

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What is Developing Resistance?

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Under the influence of antibiotics, sensitive bacterial cultures can undergo genetic transformation (mutation) to form resistant cultures.

Sensitive cell types will be killed by the agent but mutant cells will increase.

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What are multi-resistant bacteria?

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Repeated administered antibiotics (e.g. in hospitals) will increase the possibility of the development of resistant bacteria.

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What is Plasmid resistance?

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Closed loops of DNA that are responsible for resistance towards antibiotics can be transferred between resistant bacteria by processes such as conjugation and transduction.

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What is the function of B-Lactams?
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Prevent the cross-linking peptides from binding to the tetrapeptide side-chains in the cell wall bacterial cells
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What are the concentration dependent bacterial killong effects?
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Aminoglycosides and Fluoroquinolones show significant increase in the rate of bacterial killing effects when the concentration of these drugs increases above the MIC. 
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What are time-dependant bacterial killing effects?
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B-lactams (penicilins, cephalosporins and carbapenems) show time dependent bacterial killing effects. What is important is the total time that the concentration of the drug is above the MIC
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What are the antibiotics that are inhibitors of cell wall synthesis?

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Penicillin G (Benzylpenicillin)

Cephalosporins

Monobactams

Carbapenems

Vancomycin

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Which inhibitors of cell wall synthesis are bactericidal and form part of a group of B-lactam antibiotics?

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Cephalosporins

Monobactams

Carbapenems

Penicillins

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Which microorganism do we culture to get Penicillin G?

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Penicillium notatum

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What is the difference between Bactericidal and Bacteriostatic antibiotics?

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Bacteria are killed – Bactericidal effect.

Bacteria survive but do not multiply –Bacteriostatic effect.

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Q:

What is the Narrow-action spectrum resistance?

A:

When only a few bacterial cell types are affected. e.g. Penicillin G

Q:

What is Broad-spectrum resistance?

A:

When various bacterial cell types are
affected. e.g.Tetracycline

Q:

What is Developing Resistance?

A:

Under the influence of antibiotics, sensitive bacterial cultures can undergo genetic transformation (mutation) to form resistant cultures.

Sensitive cell types will be killed by the agent but mutant cells will increase.

Q:

What are multi-resistant bacteria?

A:

Repeated administered antibiotics (e.g. in hospitals) will increase the possibility of the development of resistant bacteria.

Q:

What is Plasmid resistance?

A:

Closed loops of DNA that are responsible for resistance towards antibiotics can be transferred between resistant bacteria by processes such as conjugation and transduction.

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Q:
What is the function of B-Lactams?
A:
Prevent the cross-linking peptides from binding to the tetrapeptide side-chains in the cell wall bacterial cells
Q:
What are the concentration dependent bacterial killong effects?
A:
Aminoglycosides and Fluoroquinolones show significant increase in the rate of bacterial killing effects when the concentration of these drugs increases above the MIC. 
Q:
What are time-dependant bacterial killing effects?
A:
B-lactams (penicilins, cephalosporins and carbapenems) show time dependent bacterial killing effects. What is important is the total time that the concentration of the drug is above the MIC
Q:

What are the antibiotics that are inhibitors of cell wall synthesis?

A:

Penicillin G (Benzylpenicillin)

Cephalosporins

Monobactams

Carbapenems

Vancomycin

Q:

Which inhibitors of cell wall synthesis are bactericidal and form part of a group of B-lactam antibiotics?

A:

Cephalosporins

Monobactams

Carbapenems

Penicillins

Q:

Which microorganism do we culture to get Penicillin G?

A:

Penicillium notatum

Q:

What is the difference between Bactericidal and Bacteriostatic antibiotics?

A:

Bacteria are killed – Bactericidal effect.

Bacteria survive but do not multiply –Bacteriostatic effect.

Chemotherapeutic Agents

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