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Lernmaterialien für Renal an der University of Southampton

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Case study: A 32 year old female presents to her GP with a 3 month history of increasing malaise and lethargy together with pain in her left wrist, right thumb and left knee. On examination her temperature is 37.6 °C , and there is a red rash on her cheeks. Her blood pressure is 145/95 mmHg, pulse 84 regular. The painful joints are tender and slightly swollen. Dipstick urinalysis shows RBCs and a small amount of protein. 


What is the most likely diagnosis?

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Systemic lupus erythematosus (SLE)

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Concerning the renal tubules and interstitium granulomas may be seen in the interstitium in tenal sarcoidosis?

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True

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Diagnostic test for SLE?

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Anti-ds DNA

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Why is noradrenaline given to a patient in septic shock?

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  • for the maintenance of BP, by causing vasoconstriction
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What are treatment options for stones?

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  1. Surgical with a lithotripter
  2. Ultrasound shock
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The glomerular basement membrane is full of cationic macromolecules?

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False

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Explain the relevance of asymptomatic proteinuria?

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  • important clinical finding
  • may represent developing nephrotic syndrome
  • take further interventions
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What is shown in most immunofluorescences of biopsies of patients with post-streptococcal glomerulonephritis?

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  • granular immune deposits of IgG
  • complement components in the glomeruli
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What are the links between kidney infection and stones?

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  • stones predispose to infection by:
    • causing stagnation of urine 
    • providing a site for bacteria to multiply
  • infection may produce magnesium ammonium phosphate which makes up the classical staghorn calculi 
    • chemical reaction based on bacterial urease producing ammonia
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What is pyelonephritis?

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  • inflammation of the kidney
  • it can be acute or chronic and it´s almost invariably caused by bacteria
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Define Glomerulonephritis?

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It is the inflammation of the glomeruli

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What type of hypersensitivity reaction is characterised by immune complex deposition (lupus nephritis)?

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Type 3

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Q:

Case study: A 32 year old female presents to her GP with a 3 month history of increasing malaise and lethargy together with pain in her left wrist, right thumb and left knee. On examination her temperature is 37.6 °C , and there is a red rash on her cheeks. Her blood pressure is 145/95 mmHg, pulse 84 regular. The painful joints are tender and slightly swollen. Dipstick urinalysis shows RBCs and a small amount of protein. 


What is the most likely diagnosis?

A:

Systemic lupus erythematosus (SLE)

Q:

Concerning the renal tubules and interstitium granulomas may be seen in the interstitium in tenal sarcoidosis?

A:

True

Q:

Diagnostic test for SLE?

A:

Anti-ds DNA

Q:

Why is noradrenaline given to a patient in septic shock?

A:
  • for the maintenance of BP, by causing vasoconstriction
Q:

What are treatment options for stones?

A:
  1. Surgical with a lithotripter
  2. Ultrasound shock
Mehr Karteikarten anzeigen
Q:

The glomerular basement membrane is full of cationic macromolecules?

A:

False

Q:

Explain the relevance of asymptomatic proteinuria?

A:
  • important clinical finding
  • may represent developing nephrotic syndrome
  • take further interventions
Q:

What is shown in most immunofluorescences of biopsies of patients with post-streptococcal glomerulonephritis?

A:
  • granular immune deposits of IgG
  • complement components in the glomeruli
Q:

What are the links between kidney infection and stones?

A:
  • stones predispose to infection by:
    • causing stagnation of urine 
    • providing a site for bacteria to multiply
  • infection may produce magnesium ammonium phosphate which makes up the classical staghorn calculi 
    • chemical reaction based on bacterial urease producing ammonia
Q:

What is pyelonephritis?

A:
  • inflammation of the kidney
  • it can be acute or chronic and it´s almost invariably caused by bacteria
Q:

Define Glomerulonephritis?

A:

It is the inflammation of the glomeruli

Q:

What type of hypersensitivity reaction is characterised by immune complex deposition (lupus nephritis)?

A:


Type 3

Renal

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