Immunology an der University Of Southampton | Karteikarten & Zusammenfassungen

Lernmaterialien für Immunology an der University of Southampton

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Which one of the following promotes destruction of a cell by natural killer (NK) cells? 


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Reduced numbers of MHC class 1 molecules on the cell surface

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A 64 year ole man presents with features of corticosteroid deficiency. Test show that he has circulating antibodies to adrenal cortical cells. What is the most likely underlying pathological mechanisms? 


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Failure to prevent activation of self-reactive lymphocytes

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Indicate whether the following statements about C-reactive protein are true or false? 


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It acts as an opsonin

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The following can kill cells through antibody-dependent cell-mediated cytotoxicity: true or false? 


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Eosinophil

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A 45 year old man has a pneumocystis carinii pneumonia, a bowel infection due to mycobacterium avium and candida oesophagitis. Which one of the following is most likely to explain these conditions? 


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Immunodeficiency - these are opportunistic infections, i.e. they typically occur in individuals whose immune system is abnormal 


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Neutrophils have cell surface receptors for which part of the antibody molecule? 


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Fc portion

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What are the adaptive immune cells involved in MA pathology and what are their roles? (3)

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  1. CD4+ T-cells
    • orchestrate the immune response to self-antigens
    • activate other immune cells e.g. innate, CD8+, B-cells
  2. CD8+ T-cells 
    • tissue distruction
  3. B-cells 
    • autoantibody production
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Which one of the following is most likely to activate a toll-like receptor on a macrophage? 


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Bacterial or viral component

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Match each of the following to their characteristic cell surface receptor?  

  • Antigen-presenting cell 
  • Cytotoxic T-cell 
  • Helper T-cell 
  • Immature B-cell 
  • Mast-cell 
  • MHC class 2
  • CD8
  • IgD 
  • IgE 
  • CD4 
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  • 1,2,5,3,4
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When mannan-binding lectin (MBL) binds to microbial carbohydrate, it activates which one of the following pathways? 


 

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Complement

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Which one of the following predominates in gastrointestinal secretions? 


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IgA

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A hapten is a molecule that: 


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Produces an immune response only when bound to a carrier

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  • 1936 Karteikarten
  • 76 Studierende
  • 7 Lernmaterialien

Beispielhafte Karteikarten für deinen Immunology Kurs an der University of Southampton - von Kommilitonen auf StudySmarter erstellt!

Q:

Which one of the following promotes destruction of a cell by natural killer (NK) cells? 


A:

Reduced numbers of MHC class 1 molecules on the cell surface

Q:

A 64 year ole man presents with features of corticosteroid deficiency. Test show that he has circulating antibodies to adrenal cortical cells. What is the most likely underlying pathological mechanisms? 


A:

Failure to prevent activation of self-reactive lymphocytes

Q:

Indicate whether the following statements about C-reactive protein are true or false? 


A:

It acts as an opsonin

Q:

The following can kill cells through antibody-dependent cell-mediated cytotoxicity: true or false? 


A:

Eosinophil

Q:

A 45 year old man has a pneumocystis carinii pneumonia, a bowel infection due to mycobacterium avium and candida oesophagitis. Which one of the following is most likely to explain these conditions? 


A:

Immunodeficiency - these are opportunistic infections, i.e. they typically occur in individuals whose immune system is abnormal 


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Q:

Neutrophils have cell surface receptors for which part of the antibody molecule? 


A:

Fc portion

Q:

What are the adaptive immune cells involved in MA pathology and what are their roles? (3)

A:
  1. CD4+ T-cells
    • orchestrate the immune response to self-antigens
    • activate other immune cells e.g. innate, CD8+, B-cells
  2. CD8+ T-cells 
    • tissue distruction
  3. B-cells 
    • autoantibody production
Q:

Which one of the following is most likely to activate a toll-like receptor on a macrophage? 


A:

Bacterial or viral component

Q:

Match each of the following to their characteristic cell surface receptor?  

  • Antigen-presenting cell 
  • Cytotoxic T-cell 
  • Helper T-cell 
  • Immature B-cell 
  • Mast-cell 
  • MHC class 2
  • CD8
  • IgD 
  • IgE 
  • CD4 
A:
  • 1,2,5,3,4
Q:

When mannan-binding lectin (MBL) binds to microbial carbohydrate, it activates which one of the following pathways? 


 

A:

Complement

Q:

Which one of the following predominates in gastrointestinal secretions? 


A:

IgA

Q:

A hapten is a molecule that: 


A:

Produces an immune response only when bound to a carrier

Immunology

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