MCBG 1 - Cell Components an der University Of Leicester | Karteikarten & Zusammenfassungen

Lernmaterialien für MCBG 1 - Cell Components an der University of Leicester

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Function of nucleus and associated disease.

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Function

  • RNA/DNA synthesis
  • DNA repair
  • RNA processing
  • Ribosome assembly

Disease

  • Alzheimer's and Huntington's disease
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Function of mitochondrion and associated disease.

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Function

  • ATP Synthesis

Disease

(fatty) liver disease - due to accumulation of fat in hepatic cells

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Function of plasma membrane and associated disease.

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Function

  • Transport of ions/small molecules
  • Cell morphology and movement

Disease

  • Changes in lipid state can cause muscular dystrophy
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Function of ribosomes and associated disease.

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Function

  • Protein synthesis

Disease

  • Bone marrow failure
  • Anaemia
  • Ribosomopathies - can cause cancer
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Function of lysosome and associated disease.

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Function 

  • Cellular digestion
  • Metabolism of organelles

Disease 

  • Tay Sach's disease
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Function of golgi complex and associated disease.

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Function

  • Export of proteins
  • Detoxification reactions

Disease

  • Cystic fibrosis
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Function of endoplasmic reticulum and associated disease.

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Function

  • Fatty acid, lipid and steroid synthesis

Disease

  • Type 2 diabetes
  • Parkinson's disease
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How can differences in bacterial and mammalian structure and function be exploited by medicine?

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Genetic engineering for insulin production:

  • Insulin gene inserted into gap of plasmid and reinserted into bacteria to allow for reproduction
  • Mass production

Antibiotics:

  • Allows antibiotics to enter cell through a bacterium


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What are the differences in heterochromatin and euchromatin when viewing cell in microscope?

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Heterochromatin appears darker when stained - DNA molecules are more dense as they are packed in nucleosome form and are transcriptionally inactive.

Euchromatin appears lighter when stained - DNA molecules are loosely packaged where DNA is able to be transcribed.

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Name 4 enzymes secreted by pancreatic exocrine cells.

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  • Trypsin & Chromotrypsin - digests proteins
  • Lipase - digests lipids
  • Amylase - digests carbohydrates
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What are zymogen granules?

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Zymogens are inactive precursors of enzymes.

They are only activated via a reaction e.g. hydrolysis that may cause a conformational change to allow their active site to be exposed - thus activating the enzyme for its function. A granule would contain a lot of the specific zymogens.

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Which vesicles arrive and emerge from the golgi body?

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Vesicles arrive at the cis face

  • These contain proteins from the ER

Vesicles emerge from the trans face (vesicles are seen forming)

  • These contain modified proteins
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  • 525 Karteikarten
  • 63 Studierende
  • 0 Lernmaterialien

Beispielhafte Karteikarten für deinen MCBG 1 - Cell Components Kurs an der University of Leicester - von Kommilitonen auf StudySmarter erstellt!

Q:

Function of nucleus and associated disease.

A:

Function

  • RNA/DNA synthesis
  • DNA repair
  • RNA processing
  • Ribosome assembly

Disease

  • Alzheimer's and Huntington's disease
Q:

Function of mitochondrion and associated disease.

A:

Function

  • ATP Synthesis

Disease

(fatty) liver disease - due to accumulation of fat in hepatic cells

Q:

Function of plasma membrane and associated disease.

A:

Function

  • Transport of ions/small molecules
  • Cell morphology and movement

Disease

  • Changes in lipid state can cause muscular dystrophy
Q:

Function of ribosomes and associated disease.

A:

Function

  • Protein synthesis

Disease

  • Bone marrow failure
  • Anaemia
  • Ribosomopathies - can cause cancer
Q:

Function of lysosome and associated disease.

A:

Function 

  • Cellular digestion
  • Metabolism of organelles

Disease 

  • Tay Sach's disease
Mehr Karteikarten anzeigen
Q:

Function of golgi complex and associated disease.

A:

Function

  • Export of proteins
  • Detoxification reactions

Disease

  • Cystic fibrosis
Q:

Function of endoplasmic reticulum and associated disease.

A:

Function

  • Fatty acid, lipid and steroid synthesis

Disease

  • Type 2 diabetes
  • Parkinson's disease
Q:

How can differences in bacterial and mammalian structure and function be exploited by medicine?

A:

Genetic engineering for insulin production:

  • Insulin gene inserted into gap of plasmid and reinserted into bacteria to allow for reproduction
  • Mass production

Antibiotics:

  • Allows antibiotics to enter cell through a bacterium


Q:

What are the differences in heterochromatin and euchromatin when viewing cell in microscope?

A:

Heterochromatin appears darker when stained - DNA molecules are more dense as they are packed in nucleosome form and are transcriptionally inactive.

Euchromatin appears lighter when stained - DNA molecules are loosely packaged where DNA is able to be transcribed.

Q:

Name 4 enzymes secreted by pancreatic exocrine cells.

A:
  • Trypsin & Chromotrypsin - digests proteins
  • Lipase - digests lipids
  • Amylase - digests carbohydrates
Q:

What are zymogen granules?

A:

Zymogens are inactive precursors of enzymes.

They are only activated via a reaction e.g. hydrolysis that may cause a conformational change to allow their active site to be exposed - thus activating the enzyme for its function. A granule would contain a lot of the specific zymogens.

Q:

Which vesicles arrive and emerge from the golgi body?

A:

Vesicles arrive at the cis face

  • These contain proteins from the ER

Vesicles emerge from the trans face (vesicles are seen forming)

  • These contain modified proteins
MCBG 1 - Cell Components

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