Dermatology an der RCSI-Medical University Of Bahrain | Karteikarten & Zusammenfassungen

Lernmaterialien für Dermatology an der RCSI-Medical University of Bahrain

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DEFINITION of Eczema

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Atopic dermatitis (i.e. Eczema) is a common inflammatory skin disease characterised by intense pruritus and a chronic or chronically relapsing course 

 Often accompanied by other atopic disorders such as asthma and allergic rhino-conjunctivitis (hay fever), which develop in an age-dependent sequence referred to as the atopic march. 

 Atopy is linked to the presence of allergen-specific serum IgE antibodies, which exist in ~70% of individuals with atopic dermatitis (AD).

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PROGNOSIS of Psoriasis

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• Early onset predicts more severe disease 

• Patients with psoriasis have a reduced life span by 6 years (mainly due to to cardiovascular disease)

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COMPLICATIONS of Psoriasis

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• Systemic Associations 

   - 1/3 of patients have associated arthropathy      - Spondylitis and Sacroiliitis 

        - May be HLA-B27 positive and have associated IBD or Uveitis 

   - Accelerated atherosclerosis and associated metabolic syndrome

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AETIOLOGY of Eczema

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• There is no known single cause for AD 

• Current theories identify that AD is primarily a disease of the immune system, with cytokines being critical components to the disease. 

• The ‘hygiene hypothesis’ postulates that decreased exposure to infectious agents in early childhood increases susceptibility to atopic diseases. • Both a genetic predisposition (filaggrin gene) and environmental triggers (e.g. Irritation, epicutaneous sensitisation, microbial colonisation) have pathogenic roles in AD

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DIFFERENTIAL DIAGNOSIS of Eczema

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• Chronic dermatoses 

 Seborrheic dermatitis 

 Contact dermatitis (allergic or irritant) 

 Psoriasis (especially palmoplantar) 

 Nummular eczema (rare) 

 Asteatotic eczema 

 Lichen simplex chronicus 

• Infections and infestations 

 Scabies 

 Impetigo 

• Autoimmune 

 Dermatitis herpetiformis 

 Dermatomyositis 

• Drug 

 Photoallergic drug eruptions 

 Eczematous drug eruptions

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SEVERITY GRADING for Eczema

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Currently there are no severity grading scales in use in clinical practice

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DIFFERENTIAL DIAGNOSIS of Psoriasis

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• Eczema/atopic dermatitis (although distribution is typically different) 

• Mycosis fungoides (most common form of cutaneous T cell lymphoma)

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SYMPTOMS of Psoriasis

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• Pruritis 

• Flexural intertrigo 

• Arthralgia 

• Fever

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PROGNOSIS of Eczema

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• AD impacts all aspects of patient’s quality of life and emotional well-being 

• Patients with AD have an increased risk of cardiovascular disease

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SYMPTOMS of Eczema

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• Intense itch 

• Rash

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RISK FACTORS of Psoriasis

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• Family History 

• Stress 

• Alcohol & Smoking

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GRADING SCALES for Psoriasis

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• Psoriasis Area Severity Index (PASI) indicates the severity of the disease by combining the severity of the lesions and the area affected 

• Dermatology Life Quality Index (DLQI) used to measure the impact of the disease on the quality of life on the person

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Q:

DEFINITION of Eczema

A:

Atopic dermatitis (i.e. Eczema) is a common inflammatory skin disease characterised by intense pruritus and a chronic or chronically relapsing course 

 Often accompanied by other atopic disorders such as asthma and allergic rhino-conjunctivitis (hay fever), which develop in an age-dependent sequence referred to as the atopic march. 

 Atopy is linked to the presence of allergen-specific serum IgE antibodies, which exist in ~70% of individuals with atopic dermatitis (AD).

Q:

PROGNOSIS of Psoriasis

A:

• Early onset predicts more severe disease 

• Patients with psoriasis have a reduced life span by 6 years (mainly due to to cardiovascular disease)

Q:

COMPLICATIONS of Psoriasis

A:

• Systemic Associations 

   - 1/3 of patients have associated arthropathy      - Spondylitis and Sacroiliitis 

        - May be HLA-B27 positive and have associated IBD or Uveitis 

   - Accelerated atherosclerosis and associated metabolic syndrome

Q:

AETIOLOGY of Eczema

A:

• There is no known single cause for AD 

• Current theories identify that AD is primarily a disease of the immune system, with cytokines being critical components to the disease. 

• The ‘hygiene hypothesis’ postulates that decreased exposure to infectious agents in early childhood increases susceptibility to atopic diseases. • Both a genetic predisposition (filaggrin gene) and environmental triggers (e.g. Irritation, epicutaneous sensitisation, microbial colonisation) have pathogenic roles in AD

Q:

DIFFERENTIAL DIAGNOSIS of Eczema

A:

• Chronic dermatoses 

 Seborrheic dermatitis 

 Contact dermatitis (allergic or irritant) 

 Psoriasis (especially palmoplantar) 

 Nummular eczema (rare) 

 Asteatotic eczema 

 Lichen simplex chronicus 

• Infections and infestations 

 Scabies 

 Impetigo 

• Autoimmune 

 Dermatitis herpetiformis 

 Dermatomyositis 

• Drug 

 Photoallergic drug eruptions 

 Eczematous drug eruptions

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Q:

SEVERITY GRADING for Eczema

A:

Currently there are no severity grading scales in use in clinical practice

Q:

DIFFERENTIAL DIAGNOSIS of Psoriasis

A:

• Eczema/atopic dermatitis (although distribution is typically different) 

• Mycosis fungoides (most common form of cutaneous T cell lymphoma)

Q:

SYMPTOMS of Psoriasis

A:

• Pruritis 

• Flexural intertrigo 

• Arthralgia 

• Fever

Q:

PROGNOSIS of Eczema

A:

• AD impacts all aspects of patient’s quality of life and emotional well-being 

• Patients with AD have an increased risk of cardiovascular disease

Q:

SYMPTOMS of Eczema

A:

• Intense itch 

• Rash

Q:

RISK FACTORS of Psoriasis

A:

• Family History 

• Stress 

• Alcohol & Smoking

Q:

GRADING SCALES for Psoriasis

A:

• Psoriasis Area Severity Index (PASI) indicates the severity of the disease by combining the severity of the lesions and the area affected 

• Dermatology Life Quality Index (DLQI) used to measure the impact of the disease on the quality of life on the person

Dermatology

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