Skin - Histology an der Pomeranian Academy Of Medicine In Szczecin | Karteikarten & Zusammenfassungen

Lernmaterialien für skin - histology an der Pomeranian Academy of Medicine in Szczecin

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thick and thin skin

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thick = glabrous, smooth/nonhairy - found on palms and soles

thin = hairy skin, found everywhere else

the thickness refers to the thickness of the epidermal layer

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functions of skin

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external layer is relative impermeable to water - preventing water loss by evaporation

skin is a receptor organ, it protects organism from impart and friction injuries

melanin in the epidermis, protects from UV rays

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function of skin 

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glands, blood vessels and adipose participate in thermogulation, metabolism and exretion of various substances

vitamin D3 is formed in the skin under solar irradiation

skin can expand and cover large areas in edema and pregnandy

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epidermis - conists of?

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str. squamous keratinized epi (keratinocytes)

+ melanocytes, langerhans cells, merkel's cells

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layers of epidermis?

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stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, stratum corneum

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stratum basale 

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4/5 of keratin producing cells 

the stratum basale consists of a single layer of basophilic columnar cells resting on basal lamina, where the dermal-epidermal junction is

they are bound together with desmosomes (lateral upper surface), while hemidesmisomes bind the cells to the basal lamina

the cells contain intermediate keratin filaments, which maintains cohesion and resisting the effects of abrasion

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keratin in stratum basale

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keratin contains 6 different polypeptides

3 polypeptide form subunits of tonofilament

nine 3 polypetide chains form 10 nm filament

the tonofilamets with lower molecule wight lie with basal cells, while the heavier polypeptides lie where more differentiated cells are

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stratum basale - characterization

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intense mitotic activity and is responsible for constant renewal of epidermal cells (together with stratum spinosum)

the stratum spinosum and basale are called malpighian layer

the epidermis is nerewed every 15-30 days

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stratum spinosum

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conists of cuboidal/ slightly flattened cells, filled with keratin filaments(tonofibrils)

the cells are bound with desmosomes

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filaments role in stratum spinosum


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maintain cohesion and resistance of abrasion

where the skin has to stand against friction, it has a thicker stratum spinosum with more abundant tonofibrils and desmosomes

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stratum granulosum

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consists of 3-5 layers flattened polygonal cells filled with basophilic granules - keratohyalin granules (no membrane)

the granules contain : profilaggrin, involucrin, small proline rich protein, loricrin

the granules fuse with cell membranes and discharge glycolipid, acylglucosylceramide into intercellular spaces - the function of this is to be a water barries and a barrier to penetration by foreign materials

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general about skin

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largest organ

- 16% of body weight, 

epidermis --> dermis --> hypodermis(not part of skin,  but is subcutanous)

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Q:

thick and thin skin

A:

thick = glabrous, smooth/nonhairy - found on palms and soles

thin = hairy skin, found everywhere else

the thickness refers to the thickness of the epidermal layer

Q:

functions of skin

A:

external layer is relative impermeable to water - preventing water loss by evaporation

skin is a receptor organ, it protects organism from impart and friction injuries

melanin in the epidermis, protects from UV rays

Q:

function of skin 

A:

glands, blood vessels and adipose participate in thermogulation, metabolism and exretion of various substances

vitamin D3 is formed in the skin under solar irradiation

skin can expand and cover large areas in edema and pregnandy

Q:

epidermis - conists of?

A:

str. squamous keratinized epi (keratinocytes)

+ melanocytes, langerhans cells, merkel's cells

Q:

layers of epidermis?

A:

stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, stratum corneum

Mehr Karteikarten anzeigen
Q:

stratum basale 

A:

4/5 of keratin producing cells 

the stratum basale consists of a single layer of basophilic columnar cells resting on basal lamina, where the dermal-epidermal junction is

they are bound together with desmosomes (lateral upper surface), while hemidesmisomes bind the cells to the basal lamina

the cells contain intermediate keratin filaments, which maintains cohesion and resisting the effects of abrasion

Q:

keratin in stratum basale

A:

keratin contains 6 different polypeptides

3 polypeptide form subunits of tonofilament

nine 3 polypetide chains form 10 nm filament

the tonofilamets with lower molecule wight lie with basal cells, while the heavier polypeptides lie where more differentiated cells are

Q:

stratum basale - characterization

A:

intense mitotic activity and is responsible for constant renewal of epidermal cells (together with stratum spinosum)

the stratum spinosum and basale are called malpighian layer

the epidermis is nerewed every 15-30 days

Q:

stratum spinosum

A:

conists of cuboidal/ slightly flattened cells, filled with keratin filaments(tonofibrils)

the cells are bound with desmosomes

Q:

filaments role in stratum spinosum


A:

maintain cohesion and resistance of abrasion

where the skin has to stand against friction, it has a thicker stratum spinosum with more abundant tonofibrils and desmosomes

Q:

stratum granulosum

A:

consists of 3-5 layers flattened polygonal cells filled with basophilic granules - keratohyalin granules (no membrane)

the granules contain : profilaggrin, involucrin, small proline rich protein, loricrin

the granules fuse with cell membranes and discharge glycolipid, acylglucosylceramide into intercellular spaces - the function of this is to be a water barries and a barrier to penetration by foreign materials

Q:

general about skin

A:

largest organ

- 16% of body weight, 

epidermis --> dermis --> hypodermis(not part of skin,  but is subcutanous)

skin - histology

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