Lymphe an der Paracelsus Medizinische Privatuniversität Salzburg | Karteikarten & Zusammenfassungen

Lernmaterialien für Lymphe an der Paracelsus Medizinische Privatuniversität Salzburg

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A 22-year-old woman presents with a 3-day history of sore throat. Her temperature is 38.7°C (103°F). Physical examination reveals inflamed tonsils and swollen cervical lymph nodes. Trafficking of blood-borne lymphocytes to regional lymph nodes in this patient involves cell migration through high endothelial venules (HEVs). These specialized postcapillary venules are located primarily in which of the following regions of the patient's lymph nodes? 

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Deep cortex 

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A 45-year-old woman presents with a 2-month history of fatigue and recurrent fever. She also complains of tenderness below the right costal margin and dark urine. Physical examination reveals jaundice and mild hepatomegaly. The serum is positive for hepatitis B virus (HBV) antigens. Which of the following hepatocyte membrane proteins presents viral peptides to cytotoxic T lymphocytes in this patient? 

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CD4

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During a research seminar, you are asked to explain the differences between innate and adaptive immunity. Which of the following biological processes best accounts for the vast antigenic repertoire of the adaptive immune system? 

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Alternative splicing of receptor pre-mRNAs

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A neonate develops severe muscle cramps on the 2nd day postpartum. Laboratory studies show hypocalcemia. The neonate is subsequently diagnosed with DiGeorge syndrome. In addition to hypoparathyroidism, this neonate will be expected to have a congenital deficiency of which of the following cells? 

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B lymphocytes

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You are invited to give a research seminar on current topics in immunology. During your presentation, you are asked to explain key steps in lymphocyte differentiation. T-cell receptor gene rearrangement takes place in which of the following anatomic locations? 

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Bone marrow 

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Which of the following proteins provides an immune-histochemical marker for differentiated epithelial cells? 

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Fibronectin

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During a hematopathology conference, you are asked to discuss mechanisms of T-cell "education" in the prepubertal thymus. Which of the following cells regulates negative selection of self-reactive thymocytes in the medulla of the thymus by expressing a wide variety of tissue-specific genes? 

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Dendritic cells 

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You are involved in a translational medicine research project designed to test the efficacy of vaccine delivery using a microneedle skin patch. The premise for you experimental approach is targeted delivery of foreign proteins to which of the following antigen-presenting cells? 

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Epithelioreticular cells 

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What is the fate of Langerhans cells after they have ingested the foreign proteins that were delivered by your microneedle skin patch? 

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Formation of multinucleate giant cells 

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A 15-year-old girl presents with 5 days of fever (38°C/101°F) and sore throat. She reports that she has felt fatigued for the past week and has difficulty swallowing. Physical examination reveals generalized lymphadenopathy. The monospot test is positive. Which of the following best explains the development of swollen "glands" in this patient with infectious mononucleosis? 

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Bone marrow stem cell hyperplasia

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A 20-year-old woman with systemic lupus erythematous complains of joint pain, weight loss, and sporadic fever. Physical examination reveals a butterfly rash over the patient's cheeks (Malar skin rash). The antinuclear antibody test is positive. Polyclonal activation of B cells in this patient requires costimulatory signals from helper T cells: Which of the following B-cell surface proteins presents antigenic peptides to helper T cells during B-cell activation? 

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B-cell receptor

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Which of the following enzymes is essential for generating viral peptides for display on the surface of HBV-infected cells? 

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Alanine aminotransferase 

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Q:

A 22-year-old woman presents with a 3-day history of sore throat. Her temperature is 38.7°C (103°F). Physical examination reveals inflamed tonsils and swollen cervical lymph nodes. Trafficking of blood-borne lymphocytes to regional lymph nodes in this patient involves cell migration through high endothelial venules (HEVs). These specialized postcapillary venules are located primarily in which of the following regions of the patient's lymph nodes? 

A:

Deep cortex 

Q:

A 45-year-old woman presents with a 2-month history of fatigue and recurrent fever. She also complains of tenderness below the right costal margin and dark urine. Physical examination reveals jaundice and mild hepatomegaly. The serum is positive for hepatitis B virus (HBV) antigens. Which of the following hepatocyte membrane proteins presents viral peptides to cytotoxic T lymphocytes in this patient? 

A:

CD4

Q:

During a research seminar, you are asked to explain the differences between innate and adaptive immunity. Which of the following biological processes best accounts for the vast antigenic repertoire of the adaptive immune system? 

A:

Alternative splicing of receptor pre-mRNAs

Q:

A neonate develops severe muscle cramps on the 2nd day postpartum. Laboratory studies show hypocalcemia. The neonate is subsequently diagnosed with DiGeorge syndrome. In addition to hypoparathyroidism, this neonate will be expected to have a congenital deficiency of which of the following cells? 

A:

B lymphocytes

Q:

You are invited to give a research seminar on current topics in immunology. During your presentation, you are asked to explain key steps in lymphocyte differentiation. T-cell receptor gene rearrangement takes place in which of the following anatomic locations? 

A:

Bone marrow 

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Q:

Which of the following proteins provides an immune-histochemical marker for differentiated epithelial cells? 

A:

Fibronectin

Q:

During a hematopathology conference, you are asked to discuss mechanisms of T-cell "education" in the prepubertal thymus. Which of the following cells regulates negative selection of self-reactive thymocytes in the medulla of the thymus by expressing a wide variety of tissue-specific genes? 

A:

Dendritic cells 

Q:

You are involved in a translational medicine research project designed to test the efficacy of vaccine delivery using a microneedle skin patch. The premise for you experimental approach is targeted delivery of foreign proteins to which of the following antigen-presenting cells? 

A:

Epithelioreticular cells 

Q:

What is the fate of Langerhans cells after they have ingested the foreign proteins that were delivered by your microneedle skin patch? 

A:

Formation of multinucleate giant cells 

Q:

A 15-year-old girl presents with 5 days of fever (38°C/101°F) and sore throat. She reports that she has felt fatigued for the past week and has difficulty swallowing. Physical examination reveals generalized lymphadenopathy. The monospot test is positive. Which of the following best explains the development of swollen "glands" in this patient with infectious mononucleosis? 

A:

Bone marrow stem cell hyperplasia

Q:

A 20-year-old woman with systemic lupus erythematous complains of joint pain, weight loss, and sporadic fever. Physical examination reveals a butterfly rash over the patient's cheeks (Malar skin rash). The antinuclear antibody test is positive. Polyclonal activation of B cells in this patient requires costimulatory signals from helper T cells: Which of the following B-cell surface proteins presents antigenic peptides to helper T cells during B-cell activation? 

A:

B-cell receptor

Q:

Which of the following enzymes is essential for generating viral peptides for display on the surface of HBV-infected cells? 

A:

Alanine aminotransferase 

Lymphe

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