General Pathology an der Medical University Varna

local death in living body, due to
irreversible cell damage

- programmed cell death –
selective removal of cells without damage of surrounding tissue 

- by enzymes of other cells

– irreversible changes, preceding necrosis

- Typical for hypoxic cell death in all tissues
except the brain and adipose tissue

→ tissue destruction → pus →

ABSCESS

- cerebral infarction due to arterial oclusion

 Or necrosis caused by bacterial infection

-Tissue structure is NOT preserved

GROSS: Tissues are fragile, like cheese

HISTO: amorphous (formlose ) mass, no detectable structure

dry , wet, gas 

• external
• internal

• arterial
• venous
• capillary
• cardial

-Low levels of ATP result in loss of energy-dependent cellular functions impairing metabolism and normal homeostasis

nuclear chromatin condensation; formation of apoptotic bodies