Computational Biology an der LMU München

It decreases exponentially as the S of the match increases.

When two structures or sequences share more similarity than would be expected by chance

A collection of academic papers published in the context of an academic conference or workshop.

for distantly related proteins by virtue of low gap penalty in the algorithm

• Enormous database
• Algorithm gives back a lot of results
• Tolerant to spelling mistakes and typos

Homologous sequences originating from the same ancestor and likely exhibiting the same function

• Doesn't have a very good filtering function ( doesn't sort the results well)
• Poor quality control system (you get back non peer-reviewed results)

GenInfo Identifier. A GI number is a simple series of digits that are assigned consecutively to each sequence record processed by NCBI. The GI number bears no resemblance to the Version number of the sequence record. Each time a sequence record is changed, it is assigned a new GI number.

• Molecular Weight
• Theoretical PI
• Amino acid composition
• Atomic composition
• Extinction coefficient
• Estimated half-life
• Instability index
• Aliphatic index
• GRand AVerage of hYdropathicity (GRAVY)

E-value or expect value is a parameter that describes the number of hits one can "expect" to see by chance when searching in a database of a particular size. The lower the E-value, or the closer it is to zero, the more "significant" the match is 

- :gap

[gap] : mismatch

+: mismatch but with similar chemical properties

Textbook and Encyclopedias. These provide a compilation, evaluation, and/or synthesis of previously published research. Very good for a general understanding of biological concepts.