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endoderm
inner organs
liver, lungs, gut etc
mesoderm
bones, muscles, heart and blood vessels, kidney
ectoderm
skin, nervous system, teeth
hepatic development
start from e 8
formation of liver bud in e10
liver lobes
human: larger right, left, median, quadrate
mouse: larger left, right, median, caudate
liver blood flow
every section own blood supply
dual blood supply
portal vein
: nutrient rich blood from gastrointestinal tract, spleen and pancreas
hepatic artery
oxygenated blood from the heart
hepatic vein
also called central vein
drains deoxygenated blood back to the heart
Portal triad
at the corner of each lobule (hexagon)
branch of portal vein, hepatic artery, bile ducts and lymphatics
hepatic (central) vein in the middle of lobules!)
hepatocytes
parenchymal cells
metabolic functions, detoxification, production of secretion of bile, hormones
gastrulation
from e 3.5
formation of the three germ layers (endoderm, mesoderm, ectoderm)
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