Immunology - Chapter 8: T-cell Activation In Secondary Lymphoid Tissues an der Hochschule Bonn-Rhein-Sieg | Karteikarten & Zusammenfassungen

Lernmaterialien für Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues an der Hochschule Bonn-Rhein-Sieg

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What triggers T-cell activation?
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antigen presentation by APC
Lösung ausblenden
TESTE DEIN WISSEN
What actions can be activated by T-cell activation?
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TESTE DEIN WISSEN
- cytotoxic activation (killing of infected or tumour cells)
- differentiation into types of T helper cells
Lösung ausblenden
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Name the two regions of the TCR complex.
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α-chain, β-chain
Lösung ausblenden
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Which two characteristics do α-chain and β-chain have in common?
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- both have variable and constant region
- transmembrane part that is bound to cytoplasmic membrane
Lösung ausblenden
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How many signals are required for activation of T cells?
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TESTE DEIN WISSEN
Three
Lösung ausblenden
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Name the three signals that are needed for T cell activation. 
Lösung anzeigen
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- activation signal
- co-stimulation between B7/CD80 (on APC) and CD28 (on T cell) (signals survival)
- differentiating signal (coming from cytokines)
Lösung ausblenden
TESTE DEIN WISSEN
What can happen when the three signals of T cell activation have arrived?
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naive T cells will proliferate and differentiate into an effector T cell
Lösung ausblenden
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Which stimulation do dendritic cells need to mature?
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PAMP stimulation makes DCs mature from immature cells
Lösung ausblenden
TESTE DEIN WISSEN
What is a major difference between immature and mature DCs?
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immature DCs
- capable of phagocytosing
- not capable of migration

matures due to phagocytosis
- no longer phagocytoses
- migrate to activate T cells
Lösung ausblenden
TESTE DEIN WISSEN
Where does T cell activation take place?
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TESTE DEIN WISSEN
T cell zones
Lösung ausblenden
TESTE DEIN WISSEN
Where can the T cell zones be found?
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TESTE DEIN WISSEN
secondary lymphoid organs, such as the lymph nodes, spleen and peyer's patches
Lösung ausblenden
TESTE DEIN WISSEN
How do T and B cells always enter the lymph nodes?
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TESTE DEIN WISSEN
through high endothelial venule (HEV)
Lösung ausblenden
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Q:
What triggers T-cell activation?
A:
antigen presentation by APC
Q:
What actions can be activated by T-cell activation?
A:
- cytotoxic activation (killing of infected or tumour cells)
- differentiation into types of T helper cells
Q:
Name the two regions of the TCR complex.
A:
α-chain, β-chain
Q:
Which two characteristics do α-chain and β-chain have in common?
A:
- both have variable and constant region
- transmembrane part that is bound to cytoplasmic membrane
Q:
How many signals are required for activation of T cells?
A:
Three
Mehr Karteikarten anzeigen
Q:
Name the three signals that are needed for T cell activation. 
A:
- activation signal
- co-stimulation between B7/CD80 (on APC) and CD28 (on T cell) (signals survival)
- differentiating signal (coming from cytokines)
Q:
What can happen when the three signals of T cell activation have arrived?
A:
naive T cells will proliferate and differentiate into an effector T cell
Q:
Which stimulation do dendritic cells need to mature?
A:
PAMP stimulation makes DCs mature from immature cells
Q:
What is a major difference between immature and mature DCs?
A:
immature DCs
- capable of phagocytosing
- not capable of migration

matures due to phagocytosis
- no longer phagocytoses
- migrate to activate T cells
Q:
Where does T cell activation take place?
A:
T cell zones
Q:
Where can the T cell zones be found?
A:
secondary lymphoid organs, such as the lymph nodes, spleen and peyer's patches
Q:
How do T and B cells always enter the lymph nodes?
A:
through high endothelial venule (HEV)
Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

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