Renal an der Fachhochschule Der Diakonie | Karteikarten & Zusammenfassungen

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TESTE DEIN WISSEN

How do you calculate the clearance of PAH and how do you use this to calculate renal blood flow?


Lösung anzeigen
TESTE DEIN WISSEN
  • Calculate renal plasma flow (RPF) with the GFR equation
  • divide by 0.9 to consider the 90% clearance 
  • Renal blood flow is the Renal plasma flow divided by 1-haematocrit (e.g. 40%)
Lösung ausblenden
TESTE DEIN WISSEN

What is creatinine?

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TESTE DEIN WISSEN
  • a break down product of creatine phosphate
  • formed in muscles
  • acts to rephosphorylatye ADP to ATP via substrate level phosphorylation
Lösung ausblenden
TESTE DEIN WISSEN

Glucose reabsorption occurs in the ...?

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TESTE DEIN WISSEN

Proximal tubule

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TESTE DEIN WISSEN

What is the problem with creatinine as a biomarker for renal clearance?

Lösung anzeigen
TESTE DEIN WISSEN
  • some secretion at the proximal tubule
  • although it is freely filtered by the glomerulus and constantly produced
Lösung ausblenden
TESTE DEIN WISSEN

How does the kidney handle inulin?

Lösung anzeigen
TESTE DEIN WISSEN
  • freely filtered by the glomerulus
  • neither secreted nor reabsorbed
  • gold standard for GFR calculation
Lösung ausblenden
TESTE DEIN WISSEN

How does the kidney handle PAH?

Lösung anzeigen
TESTE DEIN WISSEN
  • it is filtered at the glomerulus and excreted into the proximal tubule
  • 90% of PAH is cleared from blood by the kidney
  • it´s a marker of renal blood flow, not for GFR
Lösung ausblenden
TESTE DEIN WISSEN

What is inulin?

Lösung anzeigen
TESTE DEIN WISSEN
  • it´s a fructose based polysaccharide
  • used as biomarkder for GFR calculation
Lösung ausblenden
TESTE DEIN WISSEN

In the presence of vasopressin, the greatest fraction of filtered water is absorbed in the ...?

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TESTE DEIN WISSEN

Proximal tubule

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TESTE DEIN WISSEN

In the absence of vasopressin, the greatest fraction of filtered water is absorbed in the ...?

Lösung anzeigen
TESTE DEIN WISSEN

Proximal tubule

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TESTE DEIN WISSEN

If the clearance of a substance which is freely filtered is less than that of inulin, ...?

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TESTE DEIN WISSEN

... there is net reabsorption of the substance in the tubules.

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TESTE DEIN WISSEN

Which unite does the GFR have?

Lösung anzeigen
TESTE DEIN WISSEN
  • litre per min
Lösung ausblenden
TESTE DEIN WISSEN

What factors affect plasma creatinine levels? (6)

Lösung anzeigen
TESTE DEIN WISSEN
  • increased muscle mass (increase creatinine plasma concentration)
  • gender (males>female)
  • age (decrease with increasing age)
  • amputees
  • malnutrition
  • GFR
Lösung ausblenden
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Q:

How do you calculate the clearance of PAH and how do you use this to calculate renal blood flow?


A:
  • Calculate renal plasma flow (RPF) with the GFR equation
  • divide by 0.9 to consider the 90% clearance 
  • Renal blood flow is the Renal plasma flow divided by 1-haematocrit (e.g. 40%)
Q:

What is creatinine?

A:
  • a break down product of creatine phosphate
  • formed in muscles
  • acts to rephosphorylatye ADP to ATP via substrate level phosphorylation
Q:

Glucose reabsorption occurs in the ...?

A:

Proximal tubule

Q:

What is the problem with creatinine as a biomarker for renal clearance?

A:
  • some secretion at the proximal tubule
  • although it is freely filtered by the glomerulus and constantly produced
Q:

How does the kidney handle inulin?

A:
  • freely filtered by the glomerulus
  • neither secreted nor reabsorbed
  • gold standard for GFR calculation
Mehr Karteikarten anzeigen
Q:

How does the kidney handle PAH?

A:
  • it is filtered at the glomerulus and excreted into the proximal tubule
  • 90% of PAH is cleared from blood by the kidney
  • it´s a marker of renal blood flow, not for GFR
Q:

What is inulin?

A:
  • it´s a fructose based polysaccharide
  • used as biomarkder for GFR calculation
Q:

In the presence of vasopressin, the greatest fraction of filtered water is absorbed in the ...?

A:

Proximal tubule

Q:

In the absence of vasopressin, the greatest fraction of filtered water is absorbed in the ...?

A:

Proximal tubule

Q:

If the clearance of a substance which is freely filtered is less than that of inulin, ...?

A:

... there is net reabsorption of the substance in the tubules.

Q:

Which unite does the GFR have?

A:
  • litre per min
Q:

What factors affect plasma creatinine levels? (6)

A:
  • increased muscle mass (increase creatinine plasma concentration)
  • gender (males>female)
  • age (decrease with increasing age)
  • amputees
  • malnutrition
  • GFR
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