Disorders Of Vit B12 And Folate Metabolism an der Bahcesehir University | Karteikarten & Zusammenfassungen

Lernmaterialien für Disorders of Vit B12 and Folate Metabolism an der Bahcesehir University

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TESTE DEIN WISSEN
Which of the following in true about pernicious anemia?

I.Vit B12 deficiency impairs metabolism of folic acid,leading to functional folate deficiency that distrubs erythropoiesis, causing immature precursors of erythrocytes to be released into circulation. (megablostic anemia)
II.Failure of IF secretion caused by autoimmune disease affecting parietal cells or from production of anti-IF antibodies.
III.Irreversible degeneration of the spinal cord as a result of failure of methylation of öne arginine residue on myelin basic protein.
IV.Failure of absorption of vit B12.
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TESTE DEIN WISSEN
All of above
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TESTE DEIN WISSEN
I. B group vit
II. Folic acid
III. Vit C 
IV. Vit K
 Which are water soluble vitamins?
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TESTE DEIN WISSEN
I,II,III
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TESTE DEIN WISSEN
Where are water soluble vitamins absorbed? 
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TESTE DEIN WISSEN
Small intestine 
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TESTE DEIN WISSEN
What do chylomicrons? How do they transport?

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TESTE DEIN WISSEN
Chylomicrons contains fat soluble vitamins. They transported via  lymph to bloodstream and eventually to liver.
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TESTE DEIN WISSEN
What is function of micelles? 
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TESTE DEIN WISSEN
To carry water soluble vitamins and dietary fat brush border for elimination
Lösung ausblenden
TESTE DEIN WISSEN
What is kidney's function in absorption of vitamins?
Lösung anzeigen
TESTE DEIN WISSEN
To filter out excesses of most water soluble vitamins and excrete them in urine
Lösung ausblenden
TESTE DEIN WISSEN
What enzymes  are vit B12 dependent on?
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TESTE DEIN WISSEN
Methylmalonyl CoA muhasebe
Leucine aminomutase 
Methionine synthase
Lösung ausblenden
TESTE DEIN WISSEN
Which of the following is true? 
1.Methylmalonyl CoA formed as an intermediate in catabolism of valine, by carboxylation of propionyl  CoA arising in catabolism of isoleucine and steroid.
2.It undergoes a vit B12 dependent rearrangement to succinyl CoA, catalyzed by methylmalonyl CoA mutase.
3.Activity of methylmalonyl CoA mutase is reduced in vit B12 deficiency, leading to an accumulation of methylmalonyl CoA and urinary excretion methylmalonic acid.
4.Assessment of vit B12 nutritional status.
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TESTE DEIN WISSEN
2,3,4
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TESTE DEIN WISSEN
Which of the following is not fat-soluble vitamin?
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TESTE DEIN WISSEN
Vit A
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TESTE DEIN WISSEN
Which of the information given about folic acid is false?
I.Folic acid stores in liver as polyglutamate derivates.
II. It is pteroylmonoglutamic acid.
III. Polyglutamate derivate containing 2-5 glutamic acid residue.
IV. Active form is tetrahydrofolate acid, it found in plasma. 
V. It carries two carbons THF derivates. (Biosynthesis)
VI. Intracellulary, we mainly see polyglutamate derivates. 
VII. Folic acid components pteridine, PABA, glutamic acid.
VIII. PABA is para-aminobenzoic acid.
IX. Pteridine and PABA -> Pteroic acid

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TESTE DEIN WISSEN
I,III,IX
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TESTE DEIN WISSEN
Which of the following is not source of folic acid biosynthesis? 
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TESTE DEIN WISSEN
Methionine
Lösung ausblenden
TESTE DEIN WISSEN
Which of the following is not inhibitors of folate metabolism ?
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TESTE DEIN WISSEN
Cancer chemotherapy drugs
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Q:
Which of the following in true about pernicious anemia?

I.Vit B12 deficiency impairs metabolism of folic acid,leading to functional folate deficiency that distrubs erythropoiesis, causing immature precursors of erythrocytes to be released into circulation. (megablostic anemia)
II.Failure of IF secretion caused by autoimmune disease affecting parietal cells or from production of anti-IF antibodies.
III.Irreversible degeneration of the spinal cord as a result of failure of methylation of öne arginine residue on myelin basic protein.
IV.Failure of absorption of vit B12.
A:
All of above
Q:
I. B group vit
II. Folic acid
III. Vit C 
IV. Vit K
 Which are water soluble vitamins?
A:
I,II,III
Q:
Where are water soluble vitamins absorbed? 
A:
Small intestine 
Q:
What do chylomicrons? How do they transport?

A:
Chylomicrons contains fat soluble vitamins. They transported via  lymph to bloodstream and eventually to liver.
Q:
What is function of micelles? 
A:
To carry water soluble vitamins and dietary fat brush border for elimination
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Q:
What is kidney's function in absorption of vitamins?
A:
To filter out excesses of most water soluble vitamins and excrete them in urine
Q:
What enzymes  are vit B12 dependent on?
A:
Methylmalonyl CoA muhasebe
Leucine aminomutase 
Methionine synthase
Q:
Which of the following is true? 
1.Methylmalonyl CoA formed as an intermediate in catabolism of valine, by carboxylation of propionyl  CoA arising in catabolism of isoleucine and steroid.
2.It undergoes a vit B12 dependent rearrangement to succinyl CoA, catalyzed by methylmalonyl CoA mutase.
3.Activity of methylmalonyl CoA mutase is reduced in vit B12 deficiency, leading to an accumulation of methylmalonyl CoA and urinary excretion methylmalonic acid.
4.Assessment of vit B12 nutritional status.
A:
2,3,4
Q:
Which of the following is not fat-soluble vitamin?
A:
Vit A
Q:
Which of the information given about folic acid is false?
I.Folic acid stores in liver as polyglutamate derivates.
II. It is pteroylmonoglutamic acid.
III. Polyglutamate derivate containing 2-5 glutamic acid residue.
IV. Active form is tetrahydrofolate acid, it found in plasma. 
V. It carries two carbons THF derivates. (Biosynthesis)
VI. Intracellulary, we mainly see polyglutamate derivates. 
VII. Folic acid components pteridine, PABA, glutamic acid.
VIII. PABA is para-aminobenzoic acid.
IX. Pteridine and PABA -> Pteroic acid

A:
I,III,IX
Q:
Which of the following is not source of folic acid biosynthesis? 
A:
Methionine
Q:
Which of the following is not inhibitors of folate metabolism ?
A:
Cancer chemotherapy drugs
Disorders of Vit B12 and Folate Metabolism

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