Medicinal Organic Chemistry an der Angeles University | Karteikarten & Zusammenfassungen

Lernmaterialien für Medicinal Organic Chemistry an der Angeles University

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Also known as mixed function oxidases and plays an important role in oxidation

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Monoxygenases

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refers to the mixed-function
oxidation of aromatic compounds
(arenes) to their corresponding
phenolic metabolites (arenols).

refers to the mixed-function
oxidation of aromatic compounds
(arenes) to their corresponding
phenolic metabolites (arenols).

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Aromatic Hydroxylation

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FUNCTIONAL GROUPS WE CAN ADD TO
DRUGS TO PRODUCE WATER-SOLUBLE, EXCEPT

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SH2

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is the transformation of drugs into
more water-soluble forms that are readily excreted

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Drug Metabolism

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It is common for drugs with functional groups like ester and amides. It is the addition of water with breakdown of molecule in blood plasma and liver

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Hydrolysis

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It is also known as conjugation reaction and it involves drug conjugation reactions which usually renders the drug inactive and water soluble and easily excreted via urine or bile

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Phase II Metabolism

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In animals, aromatic hydroxylation
is a major route of metabolism for
many drugs containing phenyl
groups.

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False

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NOMENCLATURE OF AMINO ACIDS HOMOLOGY:

I. CYP

II. Arabic Number

III. Capital Letter

IV. Arabic Number

V. Greek Letters

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I, II, III, IV only


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It show atoms and bonds that go into the page, behind the plane, away from you.

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Dashed lines

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CYP is also known as

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Cytochrome P450 enzymes

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CYP is mostly located at the endoplasmic
reticulum

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True

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When accumulated in the body especially for newborn infants, can result to having grey baby syndrome

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Chloramphenicol

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Q:

Also known as mixed function oxidases and plays an important role in oxidation

A:

Monoxygenases

Q:

refers to the mixed-function
oxidation of aromatic compounds
(arenes) to their corresponding
phenolic metabolites (arenols).

refers to the mixed-function
oxidation of aromatic compounds
(arenes) to their corresponding
phenolic metabolites (arenols).

A:

Aromatic Hydroxylation

Q:

FUNCTIONAL GROUPS WE CAN ADD TO
DRUGS TO PRODUCE WATER-SOLUBLE, EXCEPT

A:

SH2

Q:

is the transformation of drugs into
more water-soluble forms that are readily excreted

A:

Drug Metabolism

Q:

It is common for drugs with functional groups like ester and amides. It is the addition of water with breakdown of molecule in blood plasma and liver

A:

Hydrolysis

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Q:

It is also known as conjugation reaction and it involves drug conjugation reactions which usually renders the drug inactive and water soluble and easily excreted via urine or bile

A:

Phase II Metabolism

Q:

In animals, aromatic hydroxylation
is a major route of metabolism for
many drugs containing phenyl
groups.

A:

False

Q:

NOMENCLATURE OF AMINO ACIDS HOMOLOGY:

I. CYP

II. Arabic Number

III. Capital Letter

IV. Arabic Number

V. Greek Letters

A:

I, II, III, IV only


Q:

It show atoms and bonds that go into the page, behind the plane, away from you.

A:

Dashed lines

Q:

CYP is also known as

A:

Cytochrome P450 enzymes

Q:

CYP is mostly located at the endoplasmic
reticulum

A:

True

Q:

When accumulated in the body especially for newborn infants, can result to having grey baby syndrome

A:

Chloramphenicol

Medicinal Organic Chemistry

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