Pharmacokinetics at University Of The Western Cape | Flashcards & Summaries

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Lernmaterialien für pharmacokinetics an der University of the Western Cape

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TESTE DEIN WISSEN
First order elimination
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TESTE DEIN WISSEN
Amount of drug elimination in a specific time is directly proportional to amount of drug in the body.

As the amount/concentration of drug increased, the amount of drug eliminated over a specific time also increases (rate of elimination increases)

Clearance is constant
Forms a linear graph
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TESTE DEIN WISSEN
Food that induce CYP450 enzymes
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TESTE DEIN WISSEN
Braais( charcoal broiled food)
Brussel sprouts
Green leaf vegetables
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TESTE DEIN WISSEN
Volumes of distributions that you must know
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TESTE DEIN WISSEN
1. Plasma volume- 0.05L/Kg
2. Blood volume- 0.08l/ kg
Extracellular fluid- 0.2
Total blood water- 0.55
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TESTE DEIN WISSEN
Clearance
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TESTE DEIN WISSEN
Refers to the volume of plasma cleared of the drug per unit time

Measures the removal/loss of the drug from the body. 
Units: ml/min or L/Hr
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TESTE DEIN WISSEN
Zero order elimination/ saturation kinetics
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TESTE DEIN WISSEN
As the amount of drug in the body increases, the amount of drug eliminated over a specific time does not increase.
May occur in many drugs in situations of drug overdose.

Constant amount of of drug is eliminated over time regardless on the concentration increase
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TESTE DEIN WISSEN
Most drugs exist in
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TESTE DEIN WISSEN
Partial state of ionisation
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TESTE DEIN WISSEN
Differentiate between ionised and unionised molecules
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TESTE DEIN WISSEN
-Ionised molecules are more hydrophilic, unable to penetrate cell membrane ( lower lipid solubility.
- unionised molecules are lipid soluble, diffuse across a cell membrane and are hydrophobic
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TESTE DEIN WISSEN
What will happen to a weak acids in an acidic environment
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TESTE DEIN WISSEN
It will be unionized and lipophilic
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TESTE DEIN WISSEN
Most drugs are weak acids and bases, in which state are they present in a solution
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TESTE DEIN WISSEN
In a solution they are present as both ionised and unionized state
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TESTE DEIN WISSEN
Movement across a cell membrane is determined by?
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TESTE DEIN WISSEN
Pka of a drug and pH across membrane
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TESTE DEIN WISSEN
Transporters occur in.....
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TESTE DEIN WISSEN
Renal proximal tubule s
Cells comprising blood brain barrier
Hepatocytes
Intestinal epithelia
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TESTE DEIN WISSEN
What is happening to the plasma concentration (Cp) as the drug is absorbed. Orally
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TESTE DEIN WISSEN
When the drug is administered orally the concentration of the drug in the plasma increases from zero to the  (Cmax) Maximum concentration, this is called the absorption phase. After reaching Cmax the concentration of the drug slowly decreases until the minimum concentration is reached, this is called the Elimination phase
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Q:
First order elimination
A:
Amount of drug elimination in a specific time is directly proportional to amount of drug in the body.

As the amount/concentration of drug increased, the amount of drug eliminated over a specific time also increases (rate of elimination increases)

Clearance is constant
Forms a linear graph
Q:
Food that induce CYP450 enzymes
A:
Braais( charcoal broiled food)
Brussel sprouts
Green leaf vegetables
Q:
Volumes of distributions that you must know
A:
1. Plasma volume- 0.05L/Kg
2. Blood volume- 0.08l/ kg
Extracellular fluid- 0.2
Total blood water- 0.55
Q:
Clearance
A:
Refers to the volume of plasma cleared of the drug per unit time

Measures the removal/loss of the drug from the body. 
Units: ml/min or L/Hr
Q:
Zero order elimination/ saturation kinetics
A:
As the amount of drug in the body increases, the amount of drug eliminated over a specific time does not increase.
May occur in many drugs in situations of drug overdose.

Constant amount of of drug is eliminated over time regardless on the concentration increase
Mehr Karteikarten anzeigen
Q:
Most drugs exist in
A:
Partial state of ionisation
Q:
Differentiate between ionised and unionised molecules
A:
-Ionised molecules are more hydrophilic, unable to penetrate cell membrane ( lower lipid solubility.
- unionised molecules are lipid soluble, diffuse across a cell membrane and are hydrophobic
Q:
What will happen to a weak acids in an acidic environment
A:
It will be unionized and lipophilic
Q:
Most drugs are weak acids and bases, in which state are they present in a solution
A:
In a solution they are present as both ionised and unionized state
Q:
Movement across a cell membrane is determined by?
A:
Pka of a drug and pH across membrane
Q:
Transporters occur in.....
A:
Renal proximal tubule s
Cells comprising blood brain barrier
Hepatocytes
Intestinal epithelia
Q:
What is happening to the plasma concentration (Cp) as the drug is absorbed. Orally
A:
When the drug is administered orally the concentration of the drug in the plasma increases from zero to the  (Cmax) Maximum concentration, this is called the absorption phase. After reaching Cmax the concentration of the drug slowly decreases until the minimum concentration is reached, this is called the Elimination phase
pharmacokinetics

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