Endocrinology at University Of Stellenbosch | Flashcards & Summaries

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Lernmaterialien für Endocrinology an der University of Stellenbosch

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TESTE DEIN WISSEN
Define endocrine system 
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TESTE DEIN WISSEN
A chemical secreted by a cell or group of cells 
Into the blood for transport to distant target 
Exerts effect at very low concs
Lösung ausblenden
TESTE DEIN WISSEN
Classify the Hormones 
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TESTE DEIN WISSEN
Notes
Lösung ausblenden
TESTE DEIN WISSEN
What is the difference between hydrophilic and hydrophobic messenger
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TESTE DEIN WISSEN
Hydrophilic messenger: 
Hormones secreted by exocytosis from endocrine cell to blood vessel and then dissolve in blood plasma
Hydrophobic messenger: 
Hormones secreted via diffusion from endocrine cell to blood vessel where they bind to carrier proteins
Lösung ausblenden
TESTE DEIN WISSEN
How did the discovery of insulin aid in our understnsdning of hormones
Lösung anzeigen
TESTE DEIN WISSEN
Relationship between diabetes and pancreas 
Pancreatectomy on dogs= diabetes 
As long as the endocrine organ is in tact with blood supply the organ can be anywhere in the body 
Lösung ausblenden
TESTE DEIN WISSEN
Peptide Hormone 
Lösung anzeigen
TESTE DEIN WISSEN
Binds to cell membrane via cell receptor  coupled to G protein 
Induces signaling cascade 
Protein phosphorylation 
Cellular effect 
Lösung ausblenden
TESTE DEIN WISSEN
Name the various modes of secretion 
Lösung anzeigen
TESTE DEIN WISSEN
PANE 

  • Paracrine: when a cell secretes a product and the product binds to neighboring cell receptors and performs the function in the cell 
  • Autocrine: when a cell secretes a product and the product binds to the receptor on the same cell and performs function on same cell 
  • Neuro-endocrine: when a hormones moves along through the axon of a neuron to the target cell 
  • Endocrine: when a hormone is released into the circulatory system and moves along the bloodstream to target cell  
Lösung ausblenden
TESTE DEIN WISSEN
Why does aldosterone have a shorter half life 
Lösung anzeigen
TESTE DEIN WISSEN
Aldosterone = protein 
BUT NOT bound to protein carrier and is FREE in plasma
Unbound hormone diffuses into carrier protein 
Cortisol 
Estrogen 
Testosterone 

Lösung ausblenden
TESTE DEIN WISSEN
Two hormones based on solubility and their descriptions 
Lösung anzeigen
TESTE DEIN WISSEN
  • Hydrophilic: PIC
  • water soluble= can dissolve easily in plasma a d requires no carrier protein 
Peptide Hormone
Indole-amines
Catecholamines 
  • Lipophilic: ST 
  • fat soluble: cannot dissolve easily and requires carrier protein
Steroid hormones
Thyroid hormones 

Lösung ausblenden
TESTE DEIN WISSEN
Draw a diagram of protein and polypeptide hormone synthesis and release 
Lösung anzeigen
TESTE DEIN WISSEN
Diagram 
Lösung ausblenden
TESTE DEIN WISSEN
Draw the differences between preprohormones prohormones and insulin 
Lösung anzeigen
TESTE DEIN WISSEN
Diagram 
Lösung ausblenden
TESTE DEIN WISSEN
Do all cholesterol containing organs produce steroid hormones
Lösung anzeigen
TESTE DEIN WISSEN
No 
If enzyme is not present steroid hormone will not be produced 
All the enzymes for the specific hormone produced by endocrine glands MUST be present at the specific part of the endocrine gland 
Lösung ausblenden
TESTE DEIN WISSEN
Define genomic response 
Lösung anzeigen
TESTE DEIN WISSEN
Enters cell to cause an effect 
Lösung ausblenden
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Q:
Define endocrine system 
A:
A chemical secreted by a cell or group of cells 
Into the blood for transport to distant target 
Exerts effect at very low concs
Q:
Classify the Hormones 
A:
Notes
Q:
What is the difference between hydrophilic and hydrophobic messenger
A:
Hydrophilic messenger: 
Hormones secreted by exocytosis from endocrine cell to blood vessel and then dissolve in blood plasma
Hydrophobic messenger: 
Hormones secreted via diffusion from endocrine cell to blood vessel where they bind to carrier proteins
Q:
How did the discovery of insulin aid in our understnsdning of hormones
A:
Relationship between diabetes and pancreas 
Pancreatectomy on dogs= diabetes 
As long as the endocrine organ is in tact with blood supply the organ can be anywhere in the body 
Q:
Peptide Hormone 
A:
Binds to cell membrane via cell receptor  coupled to G protein 
Induces signaling cascade 
Protein phosphorylation 
Cellular effect 
Mehr Karteikarten anzeigen
Q:
Name the various modes of secretion 
A:
PANE 

  • Paracrine: when a cell secretes a product and the product binds to neighboring cell receptors and performs the function in the cell 
  • Autocrine: when a cell secretes a product and the product binds to the receptor on the same cell and performs function on same cell 
  • Neuro-endocrine: when a hormones moves along through the axon of a neuron to the target cell 
  • Endocrine: when a hormone is released into the circulatory system and moves along the bloodstream to target cell  
Q:
Why does aldosterone have a shorter half life 
A:
Aldosterone = protein 
BUT NOT bound to protein carrier and is FREE in plasma
Unbound hormone diffuses into carrier protein 
Cortisol 
Estrogen 
Testosterone 

Q:
Two hormones based on solubility and their descriptions 
A:
  • Hydrophilic: PIC
  • water soluble= can dissolve easily in plasma a d requires no carrier protein 
Peptide Hormone
Indole-amines
Catecholamines 
  • Lipophilic: ST 
  • fat soluble: cannot dissolve easily and requires carrier protein
Steroid hormones
Thyroid hormones 

Q:
Draw a diagram of protein and polypeptide hormone synthesis and release 
A:
Diagram 
Q:
Draw the differences between preprohormones prohormones and insulin 
A:
Diagram 
Q:
Do all cholesterol containing organs produce steroid hormones
A:
No 
If enzyme is not present steroid hormone will not be produced 
All the enzymes for the specific hormone produced by endocrine glands MUST be present at the specific part of the endocrine gland 
Q:
Define genomic response 
A:
Enters cell to cause an effect 
Endocrinology

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