Room 65: Biochemistry at University Of Peradeniya | Flashcards & Summaries

Room 65: Biochemistry at University of Peradeniya

Flashcards and summaries for Room 65: Biochemistry at the University of Peradeniya

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Functions of Proteoglycans

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Explain the mode of action on enzymes in terms of enzyme specificity.

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Types of Membrane Transporters
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Exemplary flashcards for Room 65: Biochemistry at the University of Peradeniya on StudySmarter:

Most Abundant GAG

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State [Describe actually] the functions of enzymes in the body.

Exemplary flashcards for Room 65: Biochemistry at the University of Peradeniya on StudySmarter:

Recall how the structure of protein molecules contribute to function of an enzyme.

Exemplary flashcards for Room 65: Biochemistry at the University of Peradeniya on StudySmarter:

State that the proper functioning of cell organelles is important to smooth cell function.
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AA Abbreviations

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Carrier Proteins

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GAG Lacking UA

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Applications of Inhibitors
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Exemplary flashcards for Room 65: Biochemistry at the University of Peradeniya on StudySmarter:

Long Term Enzyme Regulation

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Exemplary flashcards for Room 65: Biochemistry at the University of Peradeniya on StudySmarter:

Room 65: Biochemistry

Functions of Proteoglycans
  • Constituent of ECM
  • Attracts Water
  • Acts as a Barrier
  • Acts as a Lubricant in Joints
  • Release of Secretions
  • Role in Cell Migration
  • Role in Glomerular Filtration
  • Role as Anticoagulant (Hp)
  • Release LPL (Hp)
  • As a Receptor (HS)
  • Role in Cartilage Compressibility (CS, HA)
  • Role in Sclera of Eye (DS)
  • Role in Corneal Transparency (KS)

Room 65: Biochemistry

Explain the mode of action on enzymes in terms of enzyme specificity.
  • Enzymes are specific for the reactions they catalyze.
  • They interact with one or a few specific substrates,
  • catalysing only one type of chemical reaction.

Room 65: Biochemistry

Types of Membrane Transporters
  • Channel Proteins
  • Carrier Proteins

Room 65: Biochemistry

Most Abundant GAG
CS

Room 65: Biochemistry

State [Describe actually] the functions of enzymes in the body.
  • Build-up of new tissue
  • Replacement of old tissue
  • Conversion of food to energy
  • Disposal of waste materials
  • Reproduction
  • Drug targets (for treatment & control of diseases)
  • Disease diagnosis

Room 65: Biochemistry

Recall how the structure of protein molecules contribute to function of an enzyme.
Enzymes are proteins and their activities depend on the 3D structure of the amino acids that compose them.

E.g. Tertiary & Quaternary Structures

Room 65: Biochemistry

State that the proper functioning of cell organelles is important to smooth cell function.
  • Interconnected Chemical Pathways
  • Different Compartments
  • Membrane-bound organelles
  • Enzymes of Different Pathways
  • Active in Special Biochemical ENVs
  • Concentrated in Organelles
  • Regulation of Enzyme Activity
  • Internal ENV & External Stimuli
  • Gene Expression - Promote/Suppress


Room 65: Biochemistry

AA Abbreviations
  • Glycine - Gly - G
  • Alanine - Ala - A
  • Threonin - Thr - T
  • Histidine - His - H

  • Aspartic Acid - Asp - D
  • Asparagine - Asn - N
  • Tyrosine - Tyr - Y
  • Tryptophan - Trp - W

Room 65: Biochemistry

Carrier Proteins
  • Haemoglobin:
    • Oxygen
  • Albumin:
    • Free Fatty Acids (FFAs)
    • Bilirubin
    • Calcium
  • Thyroxin-Binding Globulin:
    • Thyroxin
  • Transferrin:
    • Iron

Room 65: Biochemistry

GAG Lacking UA
Keratan Sulfate (KS)
  • Galactose Instead

Room 65: Biochemistry

Applications of Inhibitors
  • Negative Feedback
    • End Point/End Product Inhibition
  • Poisons
    • Snake Bite
    • Plant Alkaloids
    • Nerve Gases
  • Medicine
    • Antibiotics
    • Sedatives
    • Stimulants

Room 65: Biochemistry

Long Term Enzyme Regulation
Enzyme Quantity Control

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