No 1 Antibiotics at University Of Medicine And Pharmacy Of Iasi | Flashcards & Summaries

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salvarsane

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1909 - Salvarsane for syphilis treatment 

(arsenic compound, highly toxic)

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fleming

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1928- Fleming descover penicillin.

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Florey and Chain

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1940 - Florey and Chain – industrial production of penicillin.

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inhibition of bacteria growth through penicillin

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antibiotic penicillin diffuses outward from colonies

first: penicillium notatum

today: penicillium chrysogenum (adapted for high yields)

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antibiotic

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- a substance produced by a microorganism

- is able to inhibit other micro-organisms in minute amounts


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bacteriostatic

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inhibit bacterial growth


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bactericidal agents

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- ex. penicillin, streptomycin

- reduce significantly (99.9%) the number of viable bacteria in the culture (killing effect)

- bactericidal effect in vivo is obtained in cooperation with the host´s defense mechanisms

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narrow vs broad spectrum

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- narrow spectrum: antibacterial agents are preferentially active againsteither gram-negative or gram-positive bacteria or only for a short list microorganism

- broad spectrum: antibacterial agents are active against both gram-positive and gram-negative bacteria

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Time dependent antibacterial agents

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the antibacterial effect depends on the achievement of active concentrations according with period of time when active concentration > MIC (minimum inhibitory concentration); 

the raise of the dose doesn’t improve the antibacterial effect 

(e.g., beta-lactam antibiotics)

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qualities of the ideal antimicrobial drug

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✓ selective toxicity
✓ broad antimicrobial spectrum
✓ good diffusion in the tissues
✓ good persistence in active form
✓ it should not produce hypersensitivity reactions

(allergy or anaphylactic shock)
✓ bacteria should not develop resistance
✓ cheap


* Skin test (+), and an anaphylactic reaction
(dyspnea, hypotension, urticaria)

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Anti-Biotic/ Anti-bacterial agent

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A substance that inhibits or destroys bacteria. Can be natural, synthetic or semi-synthetic.

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erlich

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formulated the hypothesis of selective toxicity for drugs against bacteria ("magic bullet")

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Beispielhafte Karteikarten für deinen no 1 antibiotics Kurs an der University of Medicine and Pharmacy of Iasi - von Kommilitonen auf StudySmarter erstellt!

Q:

salvarsane

A:

1909 - Salvarsane for syphilis treatment 

(arsenic compound, highly toxic)

Q:

fleming

A:

1928- Fleming descover penicillin.

Q:

Florey and Chain

A:

1940 - Florey and Chain – industrial production of penicillin.

Q:

inhibition of bacteria growth through penicillin

A:

antibiotic penicillin diffuses outward from colonies

first: penicillium notatum

today: penicillium chrysogenum (adapted for high yields)

Q:

antibiotic

A:

- a substance produced by a microorganism

- is able to inhibit other micro-organisms in minute amounts


Mehr Karteikarten anzeigen
Q:

bacteriostatic

A:

inhibit bacterial growth


Q:

bactericidal agents

A:

- ex. penicillin, streptomycin

- reduce significantly (99.9%) the number of viable bacteria in the culture (killing effect)

- bactericidal effect in vivo is obtained in cooperation with the host´s defense mechanisms

Q:

narrow vs broad spectrum

A:

- narrow spectrum: antibacterial agents are preferentially active againsteither gram-negative or gram-positive bacteria or only for a short list microorganism

- broad spectrum: antibacterial agents are active against both gram-positive and gram-negative bacteria

Q:

Time dependent antibacterial agents

A:

the antibacterial effect depends on the achievement of active concentrations according with period of time when active concentration > MIC (minimum inhibitory concentration); 

the raise of the dose doesn’t improve the antibacterial effect 

(e.g., beta-lactam antibiotics)

Q:

qualities of the ideal antimicrobial drug

A:

✓ selective toxicity
✓ broad antimicrobial spectrum
✓ good diffusion in the tissues
✓ good persistence in active form
✓ it should not produce hypersensitivity reactions

(allergy or anaphylactic shock)
✓ bacteria should not develop resistance
✓ cheap


* Skin test (+), and an anaphylactic reaction
(dyspnea, hypotension, urticaria)

Q:

Anti-Biotic/ Anti-bacterial agent

A:

A substance that inhibits or destroys bacteria. Can be natural, synthetic or semi-synthetic.

Q:

erlich

A:

formulated the hypothesis of selective toxicity for drugs against bacteria ("magic bullet")

no 1 antibiotics

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