Tissue Engineering at University Of Leeds | Flashcards & Summaries

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Lernmaterialien für tissue engineering an der University of Leeds

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what are the requirements for biomaterial scaffold?
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Mechanical transport, space for water transport, spatial organisation, cell attachment motifs, cell scale architecture and allow for cell signalling  
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What is biocompatibility 
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Acceptable and predictable response from host  
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what is biodegradable ?
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Material can be broken down 
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What is bioresorable?
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Products of breakdown can be removed safely through metabolism 
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What is porosity?
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Pores interconnected to allow fluid movement 
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What is fibronectin?
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glycoprotein important for cell adhesion. high molecular weight. Biomaterial scaffolds are treated with it 
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What are the natural polymers?
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Proteins and neurotic acids 
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What are the synthetic polymers?
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polystyrene and silicone  
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What are hydrogels?
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Made from self assembling peptides. less than 50 amino acids.
Concentration dependant and designed to self assemble in certain physiological conditions.
net charge of positive 2 needed for self assembly 
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What are natural biopolymers?
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Contain components of the ECM binding motifs. Used in remodelling tissues that constantly change, room for growth
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What are the advantages to scaffolds made from natural tissues?
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Simular to host tissue
degraded products can be expelled through metabolism
non toxic and low inflammatory
can be remodelled by cells
degradation rate can be controlled using cross linking 
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What is dynamic mechanical analysis?
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Sinusoidal wave applied to biomaterial today determine complex modulus. Frequency sweep plotted 
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Q:
what are the requirements for biomaterial scaffold?
A:
Mechanical transport, space for water transport, spatial organisation, cell attachment motifs, cell scale architecture and allow for cell signalling  
Q:
What is biocompatibility 
A:
Acceptable and predictable response from host  
Q:
what is biodegradable ?
A:
Material can be broken down 
Q:
What is bioresorable?
A:
Products of breakdown can be removed safely through metabolism 
Q:
What is porosity?
A:
Pores interconnected to allow fluid movement 
Mehr Karteikarten anzeigen
Q:
What is fibronectin?
A:
glycoprotein important for cell adhesion. high molecular weight. Biomaterial scaffolds are treated with it 
Q:
What are the natural polymers?
A:
Proteins and neurotic acids 
Q:
What are the synthetic polymers?
A:
polystyrene and silicone  
Q:
What are hydrogels?
A:
Made from self assembling peptides. less than 50 amino acids.
Concentration dependant and designed to self assemble in certain physiological conditions.
net charge of positive 2 needed for self assembly 
Q:
What are natural biopolymers?
A:
Contain components of the ECM binding motifs. Used in remodelling tissues that constantly change, room for growth
Q:
What are the advantages to scaffolds made from natural tissues?
A:
Simular to host tissue
degraded products can be expelled through metabolism
non toxic and low inflammatory
can be remodelled by cells
degradation rate can be controlled using cross linking 
Q:
What is dynamic mechanical analysis?
A:
Sinusoidal wave applied to biomaterial today determine complex modulus. Frequency sweep plotted 
tissue engineering

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