Diabetes Mellitus at University Of British Columbia | Flashcards & Summaries

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Lernmaterialien für Diabetes Mellitus an der University of British Columbia

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In clinical practice, what combos of insulin preparations are preferred 
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RAIAs + LAIAs over regular insulin in order to achieve more benefits from both ie minimize hypoglycemia and improve HbA1c and PPG levels.
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Approach to Tx of DM
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Screening
Set Targets for glycemic control
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Insulin may be administered via
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Syringe, pen, pumps(continuous SC Insulin infusion CSII)
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What is the drug interaction with Saxagliptin & Linagliptin 
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Both are major substrates of CYP3A4 and P-gP
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Other adverse effects of insulin therapy
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Lipohypertrophy (enlargement or thickening of tissue) is due to frequent use of same inj site leading to unpredictable absorption from that site. Rotate injection sites to resolve this.
Lipoatrophy, ie  skin depression is due to insulin antibodies that destroy fat at the site of injection.

Allergic rxns: not xommon with human insulins but switch products to a diff manufacturer if seen.

Immune- mediated insulin resistance: due to antibody prodn also rare. Switch products and consider <dose at initiation of the switch
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TESTE DEIN WISSEN
What is the use of RAIAs in DM?

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To promote more flexibility to control PPG b/s of faster onset of action cc with short-acting insulin
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The abdomen provides the most consistent area for absorption. True or False.
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True
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Optimal BG control is achieved by matching the timing of insulin injections with caloric intake.
True or False
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True
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Hypoglycemia with insulin therapy is usually due to
Lösung anzeigen
TESTE DEIN WISSEN
Missed meal or unusual amount of exercise
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TESTE DEIN WISSEN
Mention the different insulin analogs and brand names.
RAIAs = 
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Raa
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Less intensive regimens may be a better choice in the elderly, unwilling  unaware of hypoglycemia.
True or False 
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True
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Conventional regimens control BG & reduce the risk of long-term diabetic microvascular complications more effectively than intensive tx regimens.  True or False
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TESTE DEIN WISSEN
False
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Beispielhafte Karteikarten für deinen Diabetes Mellitus Kurs an der University of British Columbia - von Kommilitonen auf StudySmarter erstellt!

Q:
In clinical practice, what combos of insulin preparations are preferred 
A:
RAIAs + LAIAs over regular insulin in order to achieve more benefits from both ie minimize hypoglycemia and improve HbA1c and PPG levels.
Q:
Approach to Tx of DM
A:
Screening
Set Targets for glycemic control
Q:
Insulin may be administered via
A:
Syringe, pen, pumps(continuous SC Insulin infusion CSII)
Q:
What is the drug interaction with Saxagliptin & Linagliptin 
A:
Both are major substrates of CYP3A4 and P-gP
Q:
Other adverse effects of insulin therapy
A:
Lipohypertrophy (enlargement or thickening of tissue) is due to frequent use of same inj site leading to unpredictable absorption from that site. Rotate injection sites to resolve this.
Lipoatrophy, ie  skin depression is due to insulin antibodies that destroy fat at the site of injection.

Allergic rxns: not xommon with human insulins but switch products to a diff manufacturer if seen.

Immune- mediated insulin resistance: due to antibody prodn also rare. Switch products and consider <dose at initiation of the switch
Mehr Karteikarten anzeigen
Q:
What is the use of RAIAs in DM?

A:
To promote more flexibility to control PPG b/s of faster onset of action cc with short-acting insulin
Q:
The abdomen provides the most consistent area for absorption. True or False.
A:
True
Q:
Optimal BG control is achieved by matching the timing of insulin injections with caloric intake.
True or False
A:
True
Q:
Hypoglycemia with insulin therapy is usually due to
A:
Missed meal or unusual amount of exercise
Q:
Mention the different insulin analogs and brand names.
RAIAs = 
A:
Raa
Q:
Less intensive regimens may be a better choice in the elderly, unwilling  unaware of hypoglycemia.
True or False 
A:
True
Q:
Conventional regimens control BG & reduce the risk of long-term diabetic microvascular complications more effectively than intensive tx regimens.  True or False
A:
False
Diabetes Mellitus

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