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Lernmaterialien für Sun & Skin an der University of Bradford

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TESTE DEIN WISSEN
What are some of the features of sunlight?
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Vitamin D
Made up of UV light
Ultra violet light is a part of the electromagnetic spectrum
Absorbed by the skin
•Visible portion of spectrum has no effect on the skin
•Infra-red portion creates the “warmth” of the sun
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TESTE DEIN WISSEN
What are the damaging effects of uv radiation?
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TESTE DEIN WISSEN
Skin cancer
Premature ageing
Wrinkles
•Cyclobutane dimers & 6,4 PP are the major cause of DNA damage from UVB
•Seen as “finger prints of UVB damage & identified in up to half of BCC cancers
•UVB & UVA = carcinogens 
•UV radiation weakens the immune system 

-UVA: Penetrates deep into the dermis

-Causes skin aging & wrinkles. Used in tanning beds. 

-UVB: Penetrates into the epidermis/produces vitamin D

-Causes sunburns, cataracts, immune system damage, skin cancers. 
Lösung ausblenden
TESTE DEIN WISSEN
What version of vitamin D on be found in blood tests?
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TESTE DEIN WISSEN
25 hydroxycholecaliciferol 

Prolonged sun exposure does not create more vitamin D.

25-hydroxyvitamin D3 is used to measure vitamin D levels 

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TESTE DEIN WISSEN
What are some premalignant skin conditions - actinic keratosis?
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TESTE DEIN WISSEN
-Carcinoma embedded into the skin
-common in older fairer skin people 
-AK is  indicator of severe sun damage
-Flat, pink, scaly, <1cm diameter/ often felt rather than seen/sandpaper texture
-Although patients can develop a single lesion, often they have multiple lesions in the same area – referred to as “field changes”, i.e. the area has extensive sun damage
Lösung ausblenden
TESTE DEIN WISSEN
What is Bowen's disease?
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TESTE DEIN WISSEN
Carcinoma in situ (cancer cells do not invade basement membrane of epidermis)
• caused by solar damage.
•BD is more frequent in females 
•Tendency to affect the lower legs
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TESTE DEIN WISSEN
What are the 2 forms of skin cancers?
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TESTE DEIN WISSEN

malignant- 

Basal cell carcinoma (BCC)
Squamous cell carcinoma (SCC)

non-malignant-

Melanoma


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TESTE DEIN WISSEN
What are the features of basal cell carcinoma?
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TESTE DEIN WISSEN
Most common type of all non-melanoma skin cancers
•Slowly-growing tumour, locally invasive (rodent ulcer)  
•Rarely metastasizes (<0.1%) 
•Very low mortality
•Significant morbidity with direct invasion of adjacent tissues, especially when on face or near an eye
Lösung ausblenden
TESTE DEIN WISSEN
What is photo aging?
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TESTE DEIN WISSEN
Shiny  skin
Leather skin
Excess exposure to the sun

premature aging due to chronic exposure of skin to UV light, predominantly from the sun or sun beds.

Regulation of collagen production controlled by transforming growth factor-b (TGF-b) 

Activator protein 1 (AP-1) regulates collagen breakdown by a series of metalloproteinase (MMP) enzymes 

UVR generated reactive oxygen species damages fibroblasts

Increasing Activator Protein (AP)-1 -> inhibits collagen production and activates matrix metalloproteases (MMPs) -> collagen breakdown – Leading to wrinkles, solar elastosis, purpura, spider veins

Lösung ausblenden
TESTE DEIN WISSEN
What are the signs and symptoms of melanoma?
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TESTE DEIN WISSEN

Nodular BCC (most common):

•A shiny, pearly and firm nodule with 

depressed centre 

•telangiectasia, and rolled waxy border
•Most common on the face (the nose)

Superficial BCC:

•A red patch like eczema
•slightly scaling, slightly crusted, well-demarcated
•Most common on the trunk

Slow relentless growth destroys tissue locally

Untreated invades bone, cartilage

Usually 95% cure rate

Lösung ausblenden
TESTE DEIN WISSEN
What are the treatments for basal cell carcinoma?
Lösung anzeigen
TESTE DEIN WISSEN
•Surgical treatment:
-Excision

-     Mohs micrographic surgery

-Curettage / electrodessication

Cryosurgery

•Non-surgical treatment:
-Radiotherapy
-Topical photodynamic therapy
-Other topical treatments:  5-fluorouracil, Imiquimod
Lösung ausblenden
TESTE DEIN WISSEN
What are the features of squamous cell carcinoma?
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TESTE DEIN WISSEN
•Second most common  skin cancers
•in-situ SCC: cancer cells remain within the epidermis
•Invasive SCC: cancer cells have grown into dermis
•Risk of metastasis – 5-10%
Lösung ausblenden
TESTE DEIN WISSEN
What are the risk factors for squamous cell carcinoma?
Lösung anzeigen
TESTE DEIN WISSEN
•Increasing age
•Chronic UV light exposure
•Ionizing radiation (radiotherapy)
•environmental carcinogens (arsenic, aromatic hydrocarbons)
•immunosuppression (organ transplant recipients)
•chronic inflammatory conditions (i.e. chronic wounds)
•Human Papilloma Virus (HPV)
•genetic skin conditions (xeroderma pigmentosum, albinism)
•smoking and alcohol consumption - particularly for SCC of the mouth, tongue and throat
Lösung ausblenden
  • 7174 Karteikarten
  • 276 Studierende
  • 12 Lernmaterialien

Beispielhafte Karteikarten für deinen Sun & Skin Kurs an der University of Bradford - von Kommilitonen auf StudySmarter erstellt!

Q:
What are some of the features of sunlight?
A:
Vitamin D
Made up of UV light
Ultra violet light is a part of the electromagnetic spectrum
Absorbed by the skin
•Visible portion of spectrum has no effect on the skin
•Infra-red portion creates the “warmth” of the sun
Q:
What are the damaging effects of uv radiation?
A:
Skin cancer
Premature ageing
Wrinkles
•Cyclobutane dimers & 6,4 PP are the major cause of DNA damage from UVB
•Seen as “finger prints of UVB damage & identified in up to half of BCC cancers
•UVB & UVA = carcinogens 
•UV radiation weakens the immune system 

-UVA: Penetrates deep into the dermis

-Causes skin aging & wrinkles. Used in tanning beds. 

-UVB: Penetrates into the epidermis/produces vitamin D

-Causes sunburns, cataracts, immune system damage, skin cancers. 
Q:
What version of vitamin D on be found in blood tests?
A:
25 hydroxycholecaliciferol 

Prolonged sun exposure does not create more vitamin D.

25-hydroxyvitamin D3 is used to measure vitamin D levels 

Q:
What are some premalignant skin conditions - actinic keratosis?
A:
-Carcinoma embedded into the skin
-common in older fairer skin people 
-AK is  indicator of severe sun damage
-Flat, pink, scaly, <1cm diameter/ often felt rather than seen/sandpaper texture
-Although patients can develop a single lesion, often they have multiple lesions in the same area – referred to as “field changes”, i.e. the area has extensive sun damage
Q:
What is Bowen's disease?
A:
Carcinoma in situ (cancer cells do not invade basement membrane of epidermis)
• caused by solar damage.
•BD is more frequent in females 
•Tendency to affect the lower legs
Mehr Karteikarten anzeigen
Q:
What are the 2 forms of skin cancers?
A:

malignant- 

Basal cell carcinoma (BCC)
Squamous cell carcinoma (SCC)

non-malignant-

Melanoma


Q:
What are the features of basal cell carcinoma?
A:
Most common type of all non-melanoma skin cancers
•Slowly-growing tumour, locally invasive (rodent ulcer)  
•Rarely metastasizes (<0.1%) 
•Very low mortality
•Significant morbidity with direct invasion of adjacent tissues, especially when on face or near an eye
Q:
What is photo aging?
A:
Shiny  skin
Leather skin
Excess exposure to the sun

premature aging due to chronic exposure of skin to UV light, predominantly from the sun or sun beds.

Regulation of collagen production controlled by transforming growth factor-b (TGF-b) 

Activator protein 1 (AP-1) regulates collagen breakdown by a series of metalloproteinase (MMP) enzymes 

UVR generated reactive oxygen species damages fibroblasts

Increasing Activator Protein (AP)-1 -> inhibits collagen production and activates matrix metalloproteases (MMPs) -> collagen breakdown – Leading to wrinkles, solar elastosis, purpura, spider veins

Q:
What are the signs and symptoms of melanoma?
A:

Nodular BCC (most common):

•A shiny, pearly and firm nodule with 

depressed centre 

•telangiectasia, and rolled waxy border
•Most common on the face (the nose)

Superficial BCC:

•A red patch like eczema
•slightly scaling, slightly crusted, well-demarcated
•Most common on the trunk

Slow relentless growth destroys tissue locally

Untreated invades bone, cartilage

Usually 95% cure rate

Q:
What are the treatments for basal cell carcinoma?
A:
•Surgical treatment:
-Excision

-     Mohs micrographic surgery

-Curettage / electrodessication

Cryosurgery

•Non-surgical treatment:
-Radiotherapy
-Topical photodynamic therapy
-Other topical treatments:  5-fluorouracil, Imiquimod
Q:
What are the features of squamous cell carcinoma?
A:
•Second most common  skin cancers
•in-situ SCC: cancer cells remain within the epidermis
•Invasive SCC: cancer cells have grown into dermis
•Risk of metastasis – 5-10%
Q:
What are the risk factors for squamous cell carcinoma?
A:
•Increasing age
•Chronic UV light exposure
•Ionizing radiation (radiotherapy)
•environmental carcinogens (arsenic, aromatic hydrocarbons)
•immunosuppression (organ transplant recipients)
•chronic inflammatory conditions (i.e. chronic wounds)
•Human Papilloma Virus (HPV)
•genetic skin conditions (xeroderma pigmentosum, albinism)
•smoking and alcohol consumption - particularly for SCC of the mouth, tongue and throat
Sun & Skin

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