Pharmacology at University College Dublin | Flashcards & Summaries

Lernmaterialien für Pharmacology an der University College Dublin

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What is the mechanism of action of a1 selective agonists
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Direct sympathomimetic at post synaptic adrenergic  receptors
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Name the Routes for drug administration 
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Sublingual, inhalation, oral, rectal, transdermal patch, parenteral(IV), topical
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What is the meaning of First pass effect (metabolism)
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Medications are extensively metabolised by the liver
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What are the advantages and disadvantages of inhalation 
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Advantages: Rapid action, bypass digestive system, doesn’t harm lung/mucus membrane 
Disadvantages: Increased risk of infection & overdose, training needed, limited to highly soluble drugs, fear 
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What are receptor antagonists
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They bind to receptors & prevent agonist from binding, thus keeping the receptor in the inactive state. They have affinity but no intrinsic activity. They stop agonist action 
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What is the critical/effective concentration of a drug 
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The amount of a drug needed for a therapeutic effect 
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What are the advantages and disadvantages of subcutaneous drug administration 
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Advantages: Self-adminstrable, slow and complete absorption 
Disadvantages: Painful, tissue damage from irritant drugs, max 2ml injection 
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What do receptors do in terms of activity 
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Receptors generally don’t do anything. They wait for something to come along so it becomes active 
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What are the Key Goals in Drug Administration 
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1. Appropriate ROA to allow enough to allow enough sufficient absorption and distribution of drug to target tissue 
2. Achieve effective drug concentration for desired time frame
3. Determine appropriate amount, frequency, route for effective drug action
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TESTE DEIN WISSEN
What are the advantages and disadvantages of rectal drug administration 
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Advantages: bypasses liver, slow release, steady state 
Disadvantages: unpredictable absorption, not well taken by patient 
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What are the principles of pharmacodynamics 
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  • Drugs interact with receptors as agonists or antagonist 

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What is the drug treatment of asthma
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  • When allergen present, drugs block release of mediators like mast cells
  • Drugs stop inflammation. Turns off inflammatory response by binding to receptors
  • Bronchodilators help with bronco-constriction 

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  • 6266 Karteikarten
  • 238 Studierende
  • 1 Lernmaterialien

Beispielhafte Karteikarten für deinen Pharmacology Kurs an der University College Dublin - von Kommilitonen auf StudySmarter erstellt!

Q:
What is the mechanism of action of a1 selective agonists
A:
Direct sympathomimetic at post synaptic adrenergic  receptors
Q:
Name the Routes for drug administration 
A:
Sublingual, inhalation, oral, rectal, transdermal patch, parenteral(IV), topical
Q:
What is the meaning of First pass effect (metabolism)
A:
Medications are extensively metabolised by the liver
Q:
What are the advantages and disadvantages of inhalation 
A:
Advantages: Rapid action, bypass digestive system, doesn’t harm lung/mucus membrane 
Disadvantages: Increased risk of infection & overdose, training needed, limited to highly soluble drugs, fear 
Q:
What are receptor antagonists
A:
They bind to receptors & prevent agonist from binding, thus keeping the receptor in the inactive state. They have affinity but no intrinsic activity. They stop agonist action 
Mehr Karteikarten anzeigen
Q:
What is the critical/effective concentration of a drug 
A:
The amount of a drug needed for a therapeutic effect 
Q:
What are the advantages and disadvantages of subcutaneous drug administration 
A:
Advantages: Self-adminstrable, slow and complete absorption 
Disadvantages: Painful, tissue damage from irritant drugs, max 2ml injection 
Q:
What do receptors do in terms of activity 
A:
Receptors generally don’t do anything. They wait for something to come along so it becomes active 
Q:
What are the Key Goals in Drug Administration 
A:
1. Appropriate ROA to allow enough to allow enough sufficient absorption and distribution of drug to target tissue 
2. Achieve effective drug concentration for desired time frame
3. Determine appropriate amount, frequency, route for effective drug action
Q:
What are the advantages and disadvantages of rectal drug administration 
A:
Advantages: bypasses liver, slow release, steady state 
Disadvantages: unpredictable absorption, not well taken by patient 
Q:
What are the principles of pharmacodynamics 
A:
  • Drugs interact with receptors as agonists or antagonist 

Q:
What is the drug treatment of asthma
A:
  • When allergen present, drugs block release of mediators like mast cells
  • Drugs stop inflammation. Turns off inflammatory response by binding to receptors
  • Bronchodilators help with bronco-constriction 

Pharmacology

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