BC1: Enzyme at Universität zu Lübeck

Flashcards and summaries for BC1: Enzyme at the Universität zu Lübeck

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Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Katalytisches Zentrum von Serinproteasen

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Bsp. serinproteasen

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Bsp. Cysteinproteasen = Caspasen
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Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Bsp. Asparatylproteasen

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Bsp. Metalloproteasen

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

ACE-Hemmer

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Km
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Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Serinproteasen

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Oxidoreduktasen

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Transferasen

Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Hydrolasen
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Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

Lyasen

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Exemplary flashcards for BC1: Enzyme at the Universität zu Lübeck on StudySmarter:

BC1: Enzyme

Katalytisches Zentrum von Serinproteasen
  •  Ser, His, Asp

BC1: Enzyme

Bsp. serinproteasen
Chymotrypsin (Pankreas!)
-> spaltet Peptidbindungen v.a. C-ter

Thrombin
->s.o.

BC1: Enzyme

Bsp. Cysteinproteasen = Caspasen
Papain

BC1: Enzyme

Bsp. Asparatylproteasen
  • Renin (Angiotensin -> Angiotensin1)
  • Pepsin (Magen, HCL aktiviert es)
  • HIV-1-Protease

BC1: Enzyme

Bsp. Metalloproteasen
-Thermolysin (Zn2+)
-MMPs 
  • Collagenasen
  • ACE (Ang1-Ang2)
  • Carboxypeptidase A & B (Zn2+) = Exopeptidasen (Pankreas)

BC1: Enzyme

ACE-Hemmer
  • Captopril
  • Bei Hypertonie

BC1: Enzyme

Km
  • Substratkonz bei halbmaximaler Geschwindigkeit
  • Mol/L
  • Abhängig von Substrat, pH, Temperatur, Ionenstärke
  • Normal zwischen 10^-1 bis 10^-7
  • KEIN Maß für die ES-Komplex-Stärke!!

BC1: Enzyme

Serinproteasen
  • Katalytische Triade
  • Blutgerinnungskaskade
  • Inaktivator: Org. Fluorophosphate 
  • Kovalenter Enzym-Substrat-Komplex

BC1: Enzyme

Oxidoreduktasen
  • Dehydrogenasen
  • Oxygenasen
  • Oxidasen (z.B. Desaturasen)

BC1: Enzyme

Transferasen
  • Kinasen
  • Aminotransferasen
  • Glycosyltransferasen

BC1: Enzyme

Hydrolasen
  • Phosphatasen
  • Esterasen

BC1: Enzyme

Lyasen
  • Aldolasen
  • Fumarase
  • (Z.B. Adenylatcyclase)

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Enzymdiagnostik Tag 3

ENZIME

Pflanzenphys. Enzyme

Enzyme defects

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