BC 1 at Universität Würzburg

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Welche ist die Schrittmacherreaktion bei der Biosynthese der Purinnukleotide?

Austausch von Pyrophosphat in PRPP durch eine Aminogruppe

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Welche der folgenden Aussagen zur Biosynthese von GMP und AMP trifft NICHT zu?

Die gemeinsame Vorstuffe für AMP und GMP ist IMP

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Welche der folgenden Aussagen zur Biosynthese des Thymidylats ist richtig?

(unsicher: 20171 4)

Die Thymidylat-Synthase erhöht die Nucleophilie von C5 durch Addition eines Thiolats

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Unter Standardbedingungen ist die freie Standardreaktionsenthalpie DG0 der Hydrolyse von ATP zu ADP und Phosphat

negativ, und die Hydrolyse ist exergon

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Welche der Enzyme werden sowohl für Glykolyse als auch für Glykoneogenese benötigt

(5)

Aldolase

(Triosephosphatisomerase)

Phosphoglyceratkinase

Phosphoglyceratmutase

Enolase

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Irreversiblen Schritte der Glykolyse

Glucose -> Glucose-6-Phosphat

Fructose -> Fructose-1,6-Bisphosphat

Phosphoenolpyruvat -> Pyruvat

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Welches Enzym katalysiert den geschwindigkeitsbestimmenden Schritt der Glykolyse?

Phosphofructokinase

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Welches Enzym im Citratzyklus ist durch einen Mangel an FAD in seiner Aktivität direkt betroffen?

Succinatdehydrogenase

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In welchem Teilschritt des Citratzyklus wird ein Nucelosidtriphosphat gebildet?

Succinyl-CoA -> Succinat

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Bei welchen Reaktionen im Citratzyklus wird CO2 abgespalten?

Isocitrat -> a-Ketoglutarat

a-Ketoglutarat -> Succinyl-Coa

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Welche prosthetische Gruppe besitzen Aminotransferasen?

Vitamin B6

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Durch welche beiden Enzyme werden diejenigen Verbindungen synthetisiert, welche die Stickstoffatome des Harnstoffs liefern?

(unsicher 20171 16)

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BC 1 at Universität Würzburg

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