Innere III at Universität Ulm

Flashcards and summaries for Innere III at the Universität Ulm

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Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Einteilung Lymphome

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Symptome

passend zu V.a. Lymphom

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Stadieneinteilung nach Ann Arbor

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Chemotherapie-Optionen

bei Lymphomen

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Chemotherapie FC 

heißt?

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Chemotherapie CHOP

heißt?

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Indolente Lymphome

Einteilung

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Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Follikuläres Lymphom

Mittleres Erkrankungsalter 

Pathogenese

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Follicular Lymphoma International Prognostic Index (FLIPI)

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Extranodales Marginalzonenlymphom

Einteilung

Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Risikofaktoren für das extranodale 

Marginalzonenlymphom

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Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Lymphoplasmozytisches Lymphom

Synonyme, medianes Alter,

Pathomechanismus

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Exemplary flashcards for Innere III at the Universität Ulm on StudySmarter:

Innere III

Einteilung Lymphome

1. Hodgkin (10%)

2. Non-Hodgkin (90%)

2.1 B-NHL (80%)

2.2 T-NHL (20%)

2.1.1 Aggressive Lymphome (30%)

2.1.2 Indolente Lymphome (70%)

Innere III

Symptome

passend zu V.a. Lymphom

- Lk-Vergrößerung (>1,5cm)

- Schmerzen (durch Organbefall)

- B-Symptomatik

- Verringerung der gesunden Blutzellen

- Allgemeine Symptome (zB Fatique)

Innere III

Stadieneinteilung nach Ann Arbor

I. Befall einer Lk-region oder 1 extranodaler Herd

II. 2 oder mehr Lk-regionen auf der gleichen Zwerchfellseite

III. 2 oder mehr Lk-regionen bzw. Organe außerhalb des lymphatischen Systems auf beiden Zwerchfellseiten

IV. nicht lokalisierter, diffuser oder disseminierter Befall eines oder mehrerer Organe außerhalb des lymphatischen Systems mit oder ohne Befall von lymphatischen Gewebe

Innere III

Chemotherapie-Optionen

bei Lymphomen

- Alkylanzien

- Mitosehemmer (Vincristin)

- Anthrazykline (Doxorubicin), Antimetabolite (5-FU)

Innere III

Chemotherapie FC 

heißt?

- Fludarabin

- Cyclophosphamid

Innere III

Chemotherapie CHOP

heißt?

- Cyclophosphamid

- Hydroxydaunorubicin

- Oncovin

- Prednisolon

Innere III

Indolente Lymphome

Einteilung

- Follikuläres Lymphom

- Marginalzonenlymphom

- Lymphoplasmazytisches Lymphom

- chron. lymphatische Leukämie

Innere III

Follikuläres Lymphom

Mittleres Erkrankungsalter 

Pathogenese

- ca 65J


- in 90% Translokation t(14;18) mit Überexpression von BCL2

Innere III

Follicular Lymphoma International Prognostic Index (FLIPI)

jeweils 1 Punkt bei

- >60J

- Stadium III/IV

- >4 befallene Lk-regionen

- Hämoglonin <12g/dl

- LDH>Normwert

Innere III

Extranodales Marginalzonenlymphom

Einteilung

- splenisches 15%

- nodales 10%

- extranodales (MALT) 75% (Primärlokalisation v.a. Magen, Darm)

Innere III

Risikofaktoren für das extranodale 

Marginalzonenlymphom

- autoimmunerkrankungen (Sjögren, Hashimoto)

- chron. Infekte (Helicobacter p., Campylobacter, Chlamydien)

Innere III

Lymphoplasmozytisches Lymphom

Synonyme, medianes Alter,

Pathomechanismus

- Immunozyten, M. Waldenström

- 73J

- in 90% MYD88 (L265P) Mutation (Signalkaskade des Toll-like-Rez)

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