Biochemie at Universität Ulm

Flashcards and summaries for Biochemie at the Universität Ulm

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DNA Replikation:  Enzym der Primer Synthese (Prokaryonten)

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Primer

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Primersynthese bei Eukaryoten
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Leitstrang

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Folgestrang

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Telomere

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Telomerase
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Okazaki Fragmente : Länge

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PCNA (proliferating cell nuclear Antigen)

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RFC (Replikationsfaktor C)

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Gleitring, Ringklemme :  Hindert DNA Polymerase am abdissoziieren
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FEN1 (Flapsige ENdonuklease 1)

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Exemplary flashcards for Biochemie at the Universität Ulm on StudySmarter:

Biochemie

DNA Replikation:  Enzym der Primer Synthese (Prokaryonten)
Primase

Biochemie

Primer
Komplementär zur DNA Sequenz, 8-10 Nukleotide
3‘ Ende freie OH Gruppe (Für DNA Polymerase)

Biochemie

Primersynthese bei Eukaryoten
DNA Polymerase alpha

Biochemie

Leitstrang
Vorwärtsstrang, kontinuierlicher Strang
DNA Polymerase folgt Helicase, kann kontinuirlich Nukleotide verknüpfen

Biochemie

Folgestrang
DNA Polymerase arbeitet entgegengesetzt zur Helikase und stößt auf nicht getrennten Doppelstrang.  -> Muss immer wieder neu Ansetzen -> Okazaki Fragmente (DNA Ligase verbindet)

Biochemie

Telomere
Repetetive DNA an den Enden der Chromsomen, schützt wichtige Genombestandteile.
Solange die DNA Verkürzung diesen Bereich betrifft, ist das kein Problem. Aber: Lebensdauer der Zelle ist in der Länge ihrer Telomere vorprogrammiert.

Biochemie

Telomerase
Enzym, welches Telomere verlängern kann. (In hochaktiven Zellen zB Knochenmark)
Telomerase = Reverse Transkriptase

Biochemie

Okazaki Fragmente : Länge
Eukaryoten : 200bp
Prokaryoten: 1000-2000bp

Biochemie

PCNA (proliferating cell nuclear Antigen)
Bildet einen Ring (Gleitring) der sich bei der Replikation als „Ringklemme“ auf die DNA setzt. Er bindet die DNA Polyermase um sie vom abdissoziieren zu hindern.

Biochemie

RFC (Replikationsfaktor C)
Beladung der DNA mit RIngklemmen (PCNA)

Biochemie

Gleitring, Ringklemme :  Hindert DNA Polymerase am abdissoziieren
PNCA (proliferating cell nuclear Antigen)

Biochemie

FEN1 (Flapsige ENdonuklease 1)
Enzym in Eukaryoten. Verarbeitung von Okazaki Fragmenten (Trennt Primer ab)

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Biochemie 2 at

Universität Mainz

BIOCHEMIE at

Universität Göttingen

Biochemie_I at

ZHAW - Zürcher Hochschule für Angewandte Wissenschaften

biochemie at

Universität Mainz

Biochemie 💊🧪 at

Freie Universität Berlin

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