Pharmakologie - Toxikologie

Flashcards and summaries for Pharmakologie - Toxikologie at the Universität Tübingen

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Study with flashcards and summaries for the course Pharmakologie - Toxikologie at the Universität Tübingen

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

H1-Antihistaminika - Indikationen

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Einteilung H1-Antihistaminika 

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Histamin Rezeptor 3

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Histamin Rezeptor 2

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Histamin Rezeptor 1

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Propenylbenzolderivate

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Pyrrolizidinalkaloide

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Aristolochiasäure

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Solanin

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Morphin

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Glycyrrhizin

Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Zytostatische Immunsuppressiva 

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Exemplary flashcards for Pharmakologie - Toxikologie at the Universität Tübingen on StudySmarter:

Pharmakologie - Toxikologie

H1-Antihistaminika - Indikationen

1. Linderung und Prophylaxe allergischer Reaktionen

2. Hypnotikum
Diphenhydramin

3. Antiemetikum (Reisekrankheit, Kinetosen)
Dimenhydrinat
Diphenhydramin
Meclozin

Pharmakologie - Toxikologie

Einteilung H1-Antihistaminika 

1. Generation -> zentral wirksam
zusätzlich Wirkung am M-, 5HT-, alpha- Rezeptor und lokalanästhetische Wirkkomponente
Beispiele: Dimenhydrinat, Meclozin, Promethazin
Clemastin, Dimetinden

2. Generation -> (meist) nicht zentral wirksam
Beispiele: Terfenadin, Astemizol, Loratadin, Cetirizin, Levocetrizin, Desloratadin

Pharmakologie - Toxikologie

Histamin Rezeptor 3

Allgemein:
hemmt Bronchokonstriktion

ZNS:
Neurogene Inflammation

Pharmakologie - Toxikologie

Histamin Rezeptor 2

Allgemein:
Säuresekretion
Hypotension
Bronchodilatation
Flush, Cephalgie
Tachykardie
Mucusproduktion

ZNS:
Neuroendocrin

Antagonisten:
Ranitidine
Famotidine

Pharmakologie - Toxikologie

Histamin Rezeptor 1

Allgemein:
Vasodilatation (über NO)
Bronchokonstriktion
Flush, Cephalgie (Kopfschmerzen)
Tachykardie

ZNS:
Weckreaktion
Thermoregulation
Nahrungsaufnahme
Gedächtnis, Lernen

Antagonisten:
Diphenhydramin
Desloratidin

Pharmakologie - Toxikologie

Propenylbenzolderivate

Methyleugenol
Estragol
Safrol

Pharmakologie - Toxikologie

Pyrrolizidinalkaloide

Angriffspunkte von Pflanzenstoffen

Gentoxizität
Kanzerogenität

Pharmakologie - Toxikologie

Aristolochiasäure

Angriffspunkte von Pflanzenstoffe

Gentoxizität
Kanzerogenität

Pharmakologie - Toxikologie

Solanin

Neurotoxizität -> Cholinesterasehemmung

Pharmakologie - Toxikologie

Morphin

Neurotoxizität

Pharmakologie - Toxikologie

Glycyrrhizin

Lebensmittelinhaltsstoffe – in Süßholzwurzel/Lakritze

Hemmung der 11ß-Hydroxy-Steroid-Dehydrogenase 2 über Glycyrrhetinsäure -> hypermineralocorticoides Syndrom

-> Lakritzwaren über 0,2% Glycyrrhizingehalt nur in Apotheke

Pharmakologie - Toxikologie

Zytostatische Immunsuppressiva 

Hemmung der Proliferation von Immunzellen

Nebenwirkungen vor allem durch Schädigung von proliferativen Geweben (gastrointestinale Schleimhäute, Harnwege, Knochenmark)

Inhibitoren der Purinsynthese: Azathioprin, Methotrexat, Mycofenolat (+ Thymidinsynthese)
Inhibitoren der Pyrimidinsynthese: Leflunomid

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