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Flashcards and summaries for Biochemie IV at the Universität Tübingen

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Die Liganden TNF -alpha (tumor necrosis factor alpha) ,IL-1, bacteria and other pathogens binden an welche Rezeptorklasse? Wie funktioniert der Signalweg?

Welcher Transkriptionsfaktor wird aktiviert?

Rezeptorklasse: TNF-a rezeptor, IL-1 rezeptor, Toll receptor

Signalweg: I -k(kappa) B Kinase

Transkriptionsfaktor: NF - k(kappa) B

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Welche Arten der Rezeptoren gibt es?

1. Ion Channel

2. ECR (Enzyme -coppeld rezeptor)

3. GPCR (G-Protein coppled rezeptor)

4. NHR (non-hydrophile receptor)

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Was ist ein Agonist?

Agonist, mimics the function of a natural ligand (or hormone) and induces
normal response

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Was ist ein Antagonist?

Antagonist, binds to the receptor but induces no response.
Antagonist can block binding of the natural ligand and thus inhibit receptor
signalling.

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Nennen sie Beispiele für einen Intrazellulären Rezeptor.

Nuclear hormone rezeptor (NHR)

GCs (Rezeptor for NO)

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Was sind die Eigenschaften eines NHR?

modulation of transkription of target genes via direct binding of the NHR to the hormone response element (HER)

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Was sind die Liganden von einem Nuclear Receptor?

Steroid hormones:

- Estradiol, Testosterone, Progesteron, Cortisol, Aldosterone, Ecdysone

Vitamin D derivateives

Fatty acid derivatives

Vitamin A derivatives

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Welche Arten der Ausschüttung von Botenstoffen, von Zellen gibt es?

- Endokrine

- Parakrine

- Neuronal

- contact-dependent (Juxtacrine)

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Die Liganden Epinephrine, glucagon, many others binden an welche Rezeptorklasse? Wie funktioniert der Signalweg?

Welcher Transkriptionsfaktor wird exprimiert?

Welches Enzym ist an den Rezeptor gekoppelt?

Rezeptorklasse: G-Protein-coupled receptors (GPCRs)

Signalweg:

- cAMP/PKA

- PLC, IP3 /DAG/PKC

Transkriptionsfaktor: CREB

Enzym art: keine Kinase gekoppelt an Rezeptor

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Die Liganden Wnt, Wg binden an welche Rezeptorklasse? Wie funktioniert der Signalweg?

Welcher Transkriptionsfaktor wird aktiviert ?

Rezeptorklassen: Frizzled/ LRP gekoppelt

Signalweg: Disheveled --> Multiprotein complex

Transcriptionfaktor: beta- catenin /TCF

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Der Ligand Hedgehog binden an welche Rezeptorklasse? Wie funktioniert der Signalweg?

Welcher Transkriptionsfaktor wird aktiviert?

Rezeptorklasse: Patched, Smoothened

Signalweg: Multiprotein complex

Transkriptionsfaktor: Ci (activator), Ci fragment (repressor)

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Die Liganden Cytokines (Epo, prolactin) binden an welche Rezeptorklasse? Wie funktioniert der Signalweg?

Welcher Transkriptionsfaktor wird aktiviert??

Welches Art der Kinase ist an den Rezeptor gekoppelt?

Rezeptorklasse: Cytokin Rezeptoren

Signalweg: JAK Kinase

Transkriptionsfactor: STAT (signal transducer and activator of transkription) protein

Kinasen Art: Tyrosine-Kinase-associated Receptor

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Biochemie IV at Universität Tübingen

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Biochemie IV at Universität Tübingen

Flashcards and summaries for Biochemie IV at the Universität Tübingen

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