Stressoren at Universität Trier

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Stressorengruppen

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Wirkmechanismen

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Schadwirkungen

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biologische Testverfahren

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LD50

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TD50 / LC50

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NOEL

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LOEL

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NOAEL

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LOAEL

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Fremdstoffmetabolisation Phase 1

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Reduktion


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Exemplary flashcards for Stressoren at the Universität Trier on StudySmarter:

Stressoren

Stressorengruppen

  • PAK: Polyzyklisch aromatische Kohlenwasserstoffe
  • AA: Aromatische Amine
  • Metalle
  • biotische Stressoren
  • Nanomaterialien

Stressoren

Wirkmechanismen

  • Interaktion mit der DNA
  • Interaktion mit Aminosäuren/ Peptiden/ Proteinen
  • Fremdstoffmetabolismus

Stressoren

Schadwirkungen

  • akute Toxizität
  • Hautreizung
  • Proteinreaktion & Sensbilisierung
  • Mutagenität
  • Gentoxizität
  • Kanzerogenität
  • hormonell wirksame Substanzen
  • Schadwirkungen in der Umwelt

Stressoren

biologische Testverfahren

  • 3R
  • in chemico
  • in vivo: am lebenden Organismus
  • in viitro: im Reagenzglas

Stressoren

LD50

letale Dosis bei der 50% der Versuchstiere sterben

Stressoren

TD50 / LC50

toxische Dosis, bei der 50% der Veruchstiere toxische Effekte aufweisen

Stressoren

NOEL

no observed effect Level

Stressoren

LOEL

lowest observed effect level

Stressoren

NOAEL

no observed adverse effect level

Stressoren

LOAEL

lowest observed adverse effect level

Stressoren

Fremdstoffmetabolisation Phase 1

Funktionalisierung:


  • Überführung lipophiler Verbindungen in polarere, hydrophilere Metaboliten;
  •  Einführung / Freisetzung funktioneller Gruppen, die als Angriffspunkte für die
    Konjugationsreaktionen (Phase 2) dienen können.

Stressoren

Reduktion


Reduktion ist eine chemische Teilreaktion, bei der Elektronen von einem Teilchen (Atom, Ion
oder einem Molekül) aufgenommen werden)

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Biogeographische Übung

OECD/3R

Stress and Health at

University of Twente

StR at

Fachhochschule für öffentliche Verwaltung, Polizei und Rechtspflege

STRESS at

FernUniversität in Hagen

Stressmanagment at

SRH Hochschule für Gesundheit

StR at

Hochschule für den öffentlichen Dienst in Bayern

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