Histologie I at Universität Regensburg

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Aktin-assoziierte Proteine

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Zonula adhaerens

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Macula adhaerens

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Gap Junction

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Fokaler Kontakt (Zell-Matrix)

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Hemidesmosom

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Inside-Out und Outside-In Signalling

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Besonderheiten Urothel

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Stratum corneum

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Stratum granulosum

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Zonula occludens

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Stratum spinosum

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Exemplary flashcards for Histologie I at the Universität Regensburg on StudySmarter:

Histologie I

Aktin-assoziierte Proteine
Formen Zytoskelett indem sie Polymerisation von G-Aktin zu F-Aktin kontrollieren
-Thymosin ß4 verhindert Polymerisation
-Arp, WASP, VASP erhöhen Polymerisation
-Arp-2,3-Komplex induziert Verzweigungen
-Cofilin, Gelsolin erhöhen Depolymerisation

Histologie I

Zonula adhaerens
=mechanische Stabilität, interzellulärer Spalt
-Cadherine (N-/E-)
-alpha-Aktinin, Vinkulin, Plakoglobin, Catenine
-Aktin

Sonderform: Fascia adhaerens in Glanzstreifen der Kardiomyozyten

Histologie I

Macula adhaerens
=Desmosom, Interzellulärspalt mit Mittellinie
-Cadherine (Desmoglein, Desmocollin)
-Plakoglobin, Desmophilin, Plakophilin
-Intermediärfilamente

Histologie I

Gap Junction
=Nexus, Interzellulärspalt zw Poren
-Moleküle bis 1kDa (Wasser, Glukose, Aminosäuren, Kalium)
-6 Connexine=1Connexon
-keine Verankerung

Histologie I

Fokaler Kontakt (Zell-Matrix)
-Transmembran: Integrine (Alpha, Beta Untereinheit)
-Plaque: alpha-Aktinin, Vinkulin, Paxilin, Talin
-Cytoskelett: Stressfasern=gegenläufige Aktinfilamente
-Matrix: Fibronectin, Laminin, Kollagen

Histologie I

Hemidesmosom
Intermediärfilament->Plectin/BP230->a6ß4-Integrin->Kollagen XVII/Kollagen IV/Laminin 5/Kollage I/II

Histologie I

Inside-Out und Outside-In Signalling
An fokalen Kontakten
aß-Integrin wird durch Talin von innen aktiviert, geladene Form stellt Verbindung zu EZM her
Integrin wird durch Fibronectin von außen aktiviert (Komplexbildung) zur Bindungsregulation

Histologie I

Besonderheiten Urothel
-polyploide (Plasmodium) Deck-/Umbrellazellen
-Crust—>Uroplakine (Plaques)
-Reservevesikel

Histologie I

Stratum corneum
Verhornt, keine Zellkerne
Keratinozyten->Korneozyten
80% Keratin (vernetzt durch Filaggrin, Disulfidbrücken in Matrix)
Hornhülle: Envoplakin, Periplakin, Involkrin, Loricrin

Histologie I

Stratum granulosum
1-3 Lagen
Keratohyalingranula, Profilaggrin
Zonulae occludentes und Desmosomen
Lamellen-Körperchen—> Proteine und Lipide zur Versiegelung des Stratum corneum 

Histologie I

Zonula occludens
=tight junction, Abdichtung (selektive Permeabilität s. Claudin 16 Magnesium Niere)
-Transmembran: Occludin, Claudin
-Plaque: ZO1, ZO2, ZO3
-Aktin

Histologie I

Stratum spinosum
2-5 Lagen Keratinozyten
Desmosomen (—>spitzes Aussehen)
Keratinfilamentbündel
Langerhans-Zellen (Makrophagen)

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Untere Extremität

Medizinische Psychologie

KUK/ Einführung ABDOMEN

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