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Krankheitsmechanismen
Tumor viruses: Definitions and classification
Definition
viral infection induces (rare) or supports tumor formation
Krankheitsmechanismen
Tumor viruses: Definitions and classification
Classification:
• DNA viruses: several distinct families
• RNA viruses: retroviruses, others
Krankheitsmechanismen
Oncogenes:
viral genes that contribute to tumor formation
• activation of cellular proto-oncogenes
• evolution of „new“ oncogenes
Krankheitsmechanismen
RNA tumor viruses: classification
Avian tumor viruses
• avian C type, e.g. Rous sarcoma virus
Krankheitsmechanismen
RNA tumor viruses: classification
Rodent tumor viruses
Krankheitsmechanismen
RNA tumor viruses: classification
Human tumor viruses
Krankheitsmechanismen
Virus infection and human malignancies
Krankheitsmechanismen
Adenoviruses
General properties
• linear ds DNA, 36-38 kb, terminal protein
• capsid 80 nm
Krankheitsmechanismen
Adenoviruses
Target organs
• Respiratory tract
• Eyes
• Gastrointestinal tract
Krankheitsmechanismen
Adenoviruses
Pathogenesis
• Tumors in rodent models
• no human malignancies
Krankheitsmechanismen
Adenovirus E1A – a „classical“ oncogene
Gene products
• 2 mRNA-species (12S, 13S; alternative splicing),
• 12S-Protein (244 aa) sufficient for cell transformation
Krankheitsmechanismen
Adenovirus E1A – a „classical“ oncogene
Identification of cell cycle regulators as E1A-binding proteins
• pRb-family: pRb, p107, p130
• p300: co-activator (histonacetyltransferase), p400, p600
• cyclin A
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