Krankheitsmechanismen und Therapeutische Ansätze at Universität Innsbruck

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Study with flashcards and summaries for the course Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Tumor viruses: Definitions and classification

Definition

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Tumor viruses: Definitions and classification

Classification:

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Oncogenes:

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

RNA tumor viruses: classification

Avian tumor viruses

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

RNA tumor viruses: classification

Rodent tumor viruses

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

RNA tumor viruses: classification

Human tumor viruses

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Virus infection and human malignancies

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Adenoviruses

General properties

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Adenoviruses

Target organs


Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Adenoviruses

Pathogenesis

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Adenovirus E1A – a „classical“ oncogene

Gene products

Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Adenovirus E1A – a „classical“ oncogene

Identification of cell cycle regulators as E1A-binding proteins


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Exemplary flashcards for Krankheitsmechanismen und Therapeutische Ansätze at the Universität Innsbruck on StudySmarter:

Krankheitsmechanismen und Therapeutische Ansätze

Tumor viruses: Definitions and classification

Definition

viral infection induces (rare) or supports tumor formation

Krankheitsmechanismen und Therapeutische Ansätze

Tumor viruses: Definitions and classification

Classification:

• DNA viruses: several distinct families
• RNA viruses: retroviruses, others

Krankheitsmechanismen und Therapeutische Ansätze

Oncogenes:

viral genes that contribute to tumor formation
• activation of cellular proto-oncogenes
• evolution of „new“ oncogenes

Krankheitsmechanismen und Therapeutische Ansätze

RNA tumor viruses: classification

Avian tumor viruses

• avian C type, e.g. Rous sarcoma virus

Krankheitsmechanismen und Therapeutische Ansätze

RNA tumor viruses: classification

Rodent tumor viruses

  • mammalian B type, e.g. mouse mammary tumor virus (MMTV)
  • mammalian C type, e.g. Kirsten sarcoma virus

Krankheitsmechanismen und Therapeutische Ansätze

RNA tumor viruses: classification

Human tumor viruses

  • human T lymphotrophic virus (HTLV)
  • Hepatitis C Virus (HCV)


Krankheitsmechanismen und Therapeutische Ansätze

Virus infection and human malignancies

  • Viral infections are involved in 15-20% of all human malignancies worldwide
  • regional differences in virus prevalence
  • Specific cofactors required for tumorigenesis
    -> significant regional differences in tumor incidence

Krankheitsmechanismen und Therapeutische Ansätze

Adenoviruses

General properties

• linear ds DNA, 36-38 kb, terminal protein
• capsid 80 nm

Krankheitsmechanismen und Therapeutische Ansätze

Adenoviruses

Target organs


• Respiratory tract
• Eyes
• Gastrointestinal tract

Krankheitsmechanismen und Therapeutische Ansätze

Adenoviruses

Pathogenesis

• Tumors in rodent models
• no human malignancies

Krankheitsmechanismen und Therapeutische Ansätze

Adenovirus E1A – a „classical“ oncogene

Gene products

• 2 mRNA-species (12S, 13S; alternative splicing),
• 12S-Protein (244 aa) sufficient for cell transformation

Krankheitsmechanismen und Therapeutische Ansätze

Adenovirus E1A – a „classical“ oncogene

Identification of cell cycle regulators as E1A-binding proteins


• pRb-family: pRb, p107, p130
• p300: co-activator (histonacetyltransferase), p400, p600
• cyclin A

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