Protein Prediction I at TU München

Flashcards and summaries for Protein Prediction I at the TU München

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Study with flashcards and summaries for the course Protein Prediction I at the TU München

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

What is the difference between Hashing and Dynamic Programming?

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

At a higher percentage of pairwise identical residues between the target and the template we tend to have better accuracy but worse coverage.

Select the correct answers:

  1. True

  2. False

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

The inception of Cryo EM revolutionized 3D structure determination due to its superior resolution.

Select the correct answers:

  1. False

  2. True

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

Helices and beta strands are both formed by hydrogen bonds.

Select the correct answers:

  1. True

  2. False

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

To use the NMR approach, we need to freeze a protein and assess how it responds to the magnetization.


Select the correct answers:

  1. False

  2. True

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

There is still no general prediction method for 3D structure?

Select the correct answers:

  1. True

  2. False

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

Unlike a helix, a beta strand is formed by hydrogen bonds between amino acid residues.

Select the correct answers:

  1. False

  2. True

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

X-ray crystallography determines protein structure by forming a protein crystal and shooting X-ray beams at it.

Select the correct answers:

  1. True

  2. False

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

CASP was established to assess whether the problem of predicting structure from sequence has been solved.

Select the correct answers:

  1. True

  2. False

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

The problem of predicting the 3D structure of a protein from sequence alone is unsolvable in principle.

Select the correct answers:

  1. False

  2. True

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

Even if the aligned target residue has a longer side chain than a template residue, we can still try to fit it into the 3D model by shifting the neighboring residues.

Select the correct answers:

  1. True

  2. False

Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

PSI-BLAST can detect more distantly related proteins compared to BLAST.

Select the correct answers:

  1. True

  2. False

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Exemplary flashcards for Protein Prediction I at the TU München on StudySmarter:

Protein Prediction I

What is the difference between Hashing and Dynamic Programming?
-> database today has 120 million records
-> Hashing doesn’t align entire matches but (randomly picked) stretches or words
(of size 3, but today it is recommended to use 5)
-> Hashing much faster
-> Hashing more feasible, doable
-> Hashing cannot do multiple sequence alignments (like all vs all)

Protein Prediction I

At a higher percentage of pairwise identical residues between the target and the template we tend to have better accuracy but worse coverage.

  1. True

  2. False

Protein Prediction I

The inception of Cryo EM revolutionized 3D structure determination due to its superior resolution.

  1. False

  2. True

Protein Prediction I

Helices and beta strands are both formed by hydrogen bonds.

  1. True

  2. False

Protein Prediction I

To use the NMR approach, we need to freeze a protein and assess how it responds to the magnetization.


  1. False

  2. True

Protein Prediction I

There is still no general prediction method for 3D structure?

  1. True

  2. False

Protein Prediction I

Unlike a helix, a beta strand is formed by hydrogen bonds between amino acid residues.

  1. False

  2. True

Protein Prediction I

X-ray crystallography determines protein structure by forming a protein crystal and shooting X-ray beams at it.

  1. True

  2. False

Protein Prediction I

CASP was established to assess whether the problem of predicting structure from sequence has been solved.

  1. True

  2. False

Protein Prediction I

The problem of predicting the 3D structure of a protein from sequence alone is unsolvable in principle.

  1. False

  2. True

Protein Prediction I

Even if the aligned target residue has a longer side chain than a template residue, we can still try to fit it into the 3D model by shifting the neighboring residues.

  1. True

  2. False

Protein Prediction I

PSI-BLAST can detect more distantly related proteins compared to BLAST.

  1. True

  2. False

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