Genomik at TU München

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Epigenetics

Exemplary flashcards for Genomik at the TU München on StudySmarter:

epigenetic trait

Exemplary flashcards for Genomik at the TU München on StudySmarter:

writers

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readers

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eraser

Exemplary flashcards for Genomik at the TU München on StudySmarter:

epigenetic landscape

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epigenetic landscape ~ differentiation


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epigenetic landscape ~ pluripotency

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epigenetic landscape ~ today's understanding

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terminally differentiated cells ~ characteristic

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chromatin

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active chromatin

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Exemplary flashcards for Genomik at the TU München on StudySmarter:

Genomik

Epigenetics

describes stable changes in the regulation of gene expression without a change in DNA sequences

Genomik

epigenetic trait

is a stably (mitotically/ meiotically) heritable phenotype resulting from changes in a chromosome without changes in the DNA sequence

Genomik

writers

DNA methyl transferases (DNMTs)

catalyse DNA methylation

thereby writing methylation patterns onto DNA

eg DNMT1, DNMT3a, DNMT3b

Genomik

readers

reader proteins bind to histone marks and interpret the mark

eg by recruiting other factors, which add/ remove further histone marks/ by regulating transcription

Genomik

eraser

TET = ten eleven translocation

enzymes oxidise the 5' methyl group to 5' hydroxymethyl = cytosin

Genomik

epigenetic landscape

serves as a model of tissue determination during development

Genomik

epigenetic landscape ~ differentiation


from pluripotent stem cell to terminally differentiated cells

Genomik

epigenetic landscape ~ pluripotency

from terminally differentiated cells to pluripotent stem cells

also via reprogramming in modern science

Genomik

epigenetic landscape ~ today's understanding

pluripotent stem cell -> lineage - specific cell -> endo-/ meso-/ ectoderm - specific progenitor cells

-> terminally differentiated cells

Genomik

terminally differentiated cells ~ characteristic

do not proliferate anymore

Genomik

chromatin

chromosomal substance consisting of DNA and associated proteins

Genomik

active chromatin

open

genes are accessible = permissive for transcription

characterized DNA demethylation and histone acetylation

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Entwicklungsgenetik Pflanzen

Grundlagen Biologie der Organismen

Zellbiologie

Grundpraktikum Strukturen, Gewebe, Tieren

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