Pharmacology at Sheffield Hallam University | Flashcards & Summaries

Lernmaterialien für Pharmacology an der Sheffield Hallam University

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What is a Toxin?

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A poison of biological origin.

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What are the two ways drugs can act on ion channels? 

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  • They can be blockers and block the channel's permeation
  • They can be modulators and either increase or decrease opening probability
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Which of these are excitatory neurotransmitters?

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GABA

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Fluorouracil binds to an enzyme that causes the inhibition of a down-stream step in DNA synthesis. What is this an example of?

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Inhibitor

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What are the order of events after you take a pill?

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  1. Absorption
  2. Distribution
  3. Metabolism
  4. Elimination
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What are the key concerns of the pharmaceutical industry?

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  • Drug not having its desired effect
  • Adverse drug reactions (ADR)
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Which of these receptors is direct?

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Metabotropic

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Topomax is an anti-seizure drug that targets ion channels. How does it work?

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Topomax binds to sodium channels and modulates the flow of sodium ions.

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What happens when the neurotransmitter is inhibitory?

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Two neurotransmitter molecules will bind to a chlorine channel. The M2 unit will change conformation, allowing Cl ions to flow in, hyperpolarising the cell.

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Define a Drug Interaction

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When the administration of one drug modifies the effect of another.

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What amino acids are aromatic and so will take part in hydrophobic interactions with drugs?

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Phenylalanine, tryptophan, and tyrosine

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What are the current treatment approaches?

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  • Protocol-based treatment
  • Trial & error treatment
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Beispielhafte Karteikarten für deinen Pharmacology Kurs an der Sheffield Hallam University - von Kommilitonen auf StudySmarter erstellt!

Q:

What is a Toxin?

A:

A poison of biological origin.

Q:

What are the two ways drugs can act on ion channels? 

A:
  • They can be blockers and block the channel's permeation
  • They can be modulators and either increase or decrease opening probability
Q:

Which of these are excitatory neurotransmitters?

A:

GABA

Q:

Fluorouracil binds to an enzyme that causes the inhibition of a down-stream step in DNA synthesis. What is this an example of?

A:

Inhibitor

Q:

What are the order of events after you take a pill?

A:
  1. Absorption
  2. Distribution
  3. Metabolism
  4. Elimination
Mehr Karteikarten anzeigen
Q:

What are the key concerns of the pharmaceutical industry?

A:
  • Drug not having its desired effect
  • Adverse drug reactions (ADR)
Q:

Which of these receptors is direct?

A:

Metabotropic

Q:

Topomax is an anti-seizure drug that targets ion channels. How does it work?

A:

Topomax binds to sodium channels and modulates the flow of sodium ions.

Q:

What happens when the neurotransmitter is inhibitory?

A:

Two neurotransmitter molecules will bind to a chlorine channel. The M2 unit will change conformation, allowing Cl ions to flow in, hyperpolarising the cell.

Q:

Define a Drug Interaction

A:

When the administration of one drug modifies the effect of another.

Q:

What amino acids are aromatic and so will take part in hydrophobic interactions with drugs?

A:

Phenylalanine, tryptophan, and tyrosine

Q:

What are the current treatment approaches?

A:
  • Protocol-based treatment
  • Trial & error treatment
Pharmacology

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