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Lernmaterialien für Antimicrobial Agents in MicroBio an der Sefako Makgatho Health Sciences University

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TESTE DEIN WISSEN
Discuss 2 types of AM Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
What's the machanism of action of BEYA-LACTAMS

Lösung anzeigen
TESTE DEIN WISSEN
-BETA-LACTAMS RINGS
-Bind the PBPs in the cell wall
( carboxypeptidases, transglycolases, transpeptidases)

● Penicillins
● Cephalosporins
● Monobactams
● Carbapenems
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Name two groups of inhibitors of cell wall synthesis. 
Lösung anzeigen
TESTE DEIN WISSEN
The 2 main groups of antibiotics that are active against the cell wall
1. BETA-LACTAMS
2. GLYCOPEPTIDES
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Discuss 2 types of AM Resistance 
Lösung anzeigen
TESTE DEIN WISSEN
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Lösung ausblenden
TESTE DEIN WISSEN
Name 4 types of beta-lactams

Lösung anzeigen
TESTE DEIN WISSEN
1. Penicillins
2. Cephalosporins
3. Monobactams
4. Carbapenems
Lösung ausblenden
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Q:
Discuss 2 types of AM Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
What's the machanism of action of BEYA-LACTAMS

A:
-BETA-LACTAMS RINGS
-Bind the PBPs in the cell wall
( carboxypeptidases, transglycolases, transpeptidases)

● Penicillins
● Cephalosporins
● Monobactams
● Carbapenems
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Name two groups of inhibitors of cell wall synthesis. 
A:
The 2 main groups of antibiotics that are active against the cell wall
1. BETA-LACTAMS
2. GLYCOPEPTIDES
Mehr Karteikarten anzeigen
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Discuss the 2 types of AM resistance 
1. Natural/ Intrinsic resistance 
2. Acquired Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Discuss 2 types of AM Resistance 
A:
Natural / Intrinsic Resistance 
● Resistance resulting from the normal genetic, structural or physiological state 
E.g Lack of target site
-mycoplasmas do not have a cell wall and are naturally resistant  to cell wall inhibitors.

Acquired Resistance 
● Resistance that develop after the exposure 
● Genotypic level 
  - Mutation of genes
  - Acquisition of resistant genes
    ( gene transfer mechanisms- plasmids, transposons)
Q:
Name 4 types of beta-lactams

A:
1. Penicillins
2. Cephalosporins
3. Monobactams
4. Carbapenems
Antimicrobial Agents in MicroBio

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