Stickstoffmonoxid NO at RWTH Aachen

Flashcards and summaries for Stickstoffmonoxid NO at the RWTH Aachen

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Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

Syntheseweg des NO

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

Isoemzyme der NO - Synthetasen

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

wie wird die eNos kontrolliert?
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Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

was wird von NO beeinflusst?

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

wichtigste, therapeutisch nutzbare Wirkung von NO

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

enzymatische NO- Donatoren

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

nicht enzymatische NO- Donatoren
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Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

anwendung von NO Donatoren

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

womit dürfen NO Donatoren nie kombiniert werden?

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Molsidomin

Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

enzymatische NO-Donatoren - wirkmechanismus
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Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

pharmakokinetik enzymatischer NO Donatoren

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Exemplary flashcards for Stickstoffmonoxid NO at the RWTH Aachen on StudySmarter:

Stickstoffmonoxid NO

Syntheseweg des NO
Arginin -> NO + Citrullin

Stickstoffmonoxid NO

Isoemzyme der NO - Synthetasen
 eNOS (endothel, kardiovaskulär)
 iNOS (Immunsystem)
 nNOS (Nervensystem)

Stickstoffmonoxid NO

wie wird die eNos kontrolliert?
Kontrolle durch Ca-Calmodulinkomplex (aktiviert)

Stickstoffmonoxid NO

was wird von NO beeinflusst?
vaskulärer Tonus
Angiogenese
Proliferation glatter Muskelzellen
Plättchenaggregation
Zellmigration

Stickstoffmonoxid NO

wichtigste, therapeutisch nutzbare Wirkung von NO
vasodilatation

Stickstoffmonoxid NO

enzymatische NO- Donatoren
 Nitroglycerin
 ISMN
 Isosorbit‐dinitrat (ISDN)

Stickstoffmonoxid NO

nicht enzymatische NO- Donatoren
 Molsidomin
 Nitroprussid‐N

Stickstoffmonoxid NO

anwendung von NO Donatoren
vasospastische Angina pectoris
hypertensive Krise
arteriosklerotisch bedingte Angina pectoris

Stickstoffmonoxid NO

womit dürfen NO Donatoren nie kombiniert werden?
PDE 5 Hemmer, Sildenaril, Viagra

Stickstoffmonoxid NO

Molsidomin
 senkt Vor‐ und Nachlast
 bei Angina pectoris und Linksherzsinsuffizienz

Stickstoffmonoxid NO

enzymatische NO-Donatoren - wirkmechanismus
Vorlastsenkung (bei niedriger Dosis nur Venen + arterielle Kollateralgefäße)
venösis Pooling = weniger zirkulierenden Volumens mit weniger kardialem O2‐Bedarf
Verringerung der Wandspannung (durch Vorlastsenkung)
bessere Durchblutung desHerzens

Stickstoffmonoxid NO

pharmakokinetik enzymatischer NO Donatoren
im Darm gut resorbiert, hoher First‐Pass‐Effekt, Metabolite werden renal
eliminiert

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Statistic

Pharmako- Stickstoffmonoxid

Stoffi ll

Stoffflüsse

Stoffflüsse

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